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PF-5190457

Name: PF-5190457
Brand: TargetMol
SKU: T16508
Price: 289 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16508Cas No. 1334782-79-4

Alias PF-05190457

PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

PF-5190457

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Purity: 99.34%

Catalog No. T16508Alias PF-05190457Cas No. 1334782-79-4

PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.34%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
Targets&IC50	Ghrelin receptor:8.36 (pKi)
In vitro	PF-5190457 demonstrates an optimal balance of ghrelin receptor pharmacology along with off-target selectivity [1].
In vivo	In human whole and dispersed islets, PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion[1].
Synonyms	PF-05190457

Chemical Properties

Molecular Weight	512.67
Formula	C₂₉H₃₂N₆OS
Cas No.	1334782-79-4
Smiles	Cc1cn2cc(CC(=O)N3CCC4(CN(C4)[C@@H]4CCc5cc(ccc45)-c4cc(C)ncn4)CC3)nc2s1
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7.1 mg/mL (13.85 mM), Sonication is recommended.

Ethanol: 100 mg/mL (195.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.9506 mL	9.7529 mL	19.5057 mL	97.5286 mL
5 mM	0.3901 mL	1.9506 mL	3.9011 mL	19.5057 mL
10 mM	0.1951 mL	0.9753 mL	1.9506 mL	9.7529 mL

Ethanol

	1mg	5mg	10mg	50mg
20 mM	0.0975 mL	0.4876 mL	0.9753 mL	4.8764 mL
50 mM	0.0390 mL	0.1951 mL	0.3901 mL	1.9506 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.9753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc