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PF-5190457

Name: PF-5190457
Brand: TargetMol
SKU: T16508
Price: 289 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16508Cas No. 1334782-79-4

Alias PF-05190457

PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

PF-5190457

🥰Excellent

Purity: 99.34%

Catalog No. T16508Alias PF-05190457Cas No. 1334782-79-4

PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
Targets&IC50	Ghrelin receptor:8.36 (pKi)
In vitro	PF-5190457 demonstrates an optimal balance of ghrelin receptor pharmacology along with off-target selectivity [1].
In vivo	In human whole and dispersed islets, PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion[1].
Synonyms	PF-05190457

Chemical Properties

Molecular Weight	512.67
Formula	C₂₉H₃₂N₆OS
Cas No.	1334782-79-4
Smiles	Cc1cn2cc(CC(=O)N3CCC4(CN(C4)[C@@H]4CCc5cc(ccc45)-c4cc(C)ncn4)CC3)nc2s1
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (487.64 mM), Sonication is recommended.

Ethanol: 100 mg/mL (195.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9506 mL	9.7529 mL	19.5057 mL	97.5286 mL
5 mM	0.3901 mL	1.9506 mL	3.9011 mL	19.5057 mL
10 mM	0.1951 mL	0.9753 mL	1.9506 mL	9.7529 mL
20 mM	0.0975 mL	0.4876 mL	0.9753 mL	4.8764 mL
50 mM	0.0390 mL	0.1951 mL	0.3901 mL	1.9506 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.9753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc