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Anti-Pirh2 Antibody (1B789) is a Mouse antibody targeting Pirh2. Anti-Pirh2 Antibody (1B789) can be used in WB,ICC,IHC,FCM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $296 | 7-10 days | |
100 μL | $427 | 7-10 days |
Description | Anti-Pirh2 Antibody (1B789) is a Mouse antibody targeting Pirh2. Anti-Pirh2 Antibody (1B789) can be used in WB,ICC,IHC,FCM. |
Alias | ZNF363, ZN363_HUMAN, Zinc finger protein 363, zinc finger CHY type, ZFP 363, ZCHY, RNF199, RING finger protein 199, RING finger and CHY zinc finger domain-containing protein 1, Ring finger and CHY zinc finger domain containing 1 E3 ubiquitin protein ligase, RCHY1, PRO1996, PIRH2F, PIRH2E, Pirh 2, p53-induced RING-H2 protein, p53 induced protein with a RING H2 domain, hPirh2, hARNIP, E3 ubiquitin-protein ligase Pirh2, CH-rich-interacting match with PLAG1, CHIMP, ARNIP, Androgen receptor N-terminal-interacting protein, Androgen receptor N terminal interacting protein |
Reactivity | Human,Rat |
Application | |
Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:100-200 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | Pirh2, also known as Androgen receptor N-terminal-interacting protein (ARNIP), ZN363 or CHIMP, has p53-induced ubiquitin-protein ligase activity, promoting p53 degradation. The protein physically interacts with p53 and the resulting degradation of p53 renders Pirh2 an oncogenic protein as the loss of p53 function contributes to malignant tumor development. The gene encoding for the protein maps to chromosome 4q21.1 and transcription of this gene is regulated by p53. Pirh2 expression decreases the level of p53 and a decrease of endogenous Pirh2 expression ups p53 levels. Pirh2 is therefore considered, together with MDM2, to be acting as a negative regulator of p53 function. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein |
Uniprot ID |
Molecular Weight | Theoretical: 30 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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