Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
2 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 449.00 | |
10 mg | In stock | $ 659.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,390.00 | |
100 mg | In stock | $ 1,880.00 | |
500 mg | In stock | $ 3,780.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 491.00 |
Description | Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo. |
In vitro | Chimmitecan was highly cytotoxic (IC50s in the nanomolar range) to a wide variety of tumor cells, including leukemia, lung cancer, gastric cancer, hepatocellular cancer, colon cancer, breast cancer, ovarian cancer, and cervical cancer, and rhabdomyosarcoma cells[1]. |
In vivo | Chimmitecan (i.v. administration, twice for HCT-116 and thrice for the other tumors per week) caused a dramatic and dose-dependent suppression of tumor growth in all four tumor models. At a dosage of 15 mg/kg, the T/C (%) values were 17.6% (HCT-116), 24.2% (MDA-MB-435), 28.2% (BEL-7402), and 23.0% (A549). when given thrice per week for 2 weeks, chimmitecan (orally administration) inhibited the growth of the A549 xenograft at dosages as low as 4.5 mg/kg, and significant antitumor activity was observed at a dosage of 9 mg/kg[1]. |
Synonyms | (S)-9-Allyl-10-hydroxycamptothecin |
Molecular Weight | 404.42 |
Formula | C23H20N2O5 |
CAS No. | 185425-25-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.05 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Chimmitecan 185425-25-6 DNA Damage/DNA Repair Topoisomerase (S)-9-Allyl-10-hydroxycamptothecin 9-Allyl-10-hydroxycamptothecin inhibitor inhibit