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Lenumlostat (Synonyms: PAT-1251, GB2064, 2007885-39-2)

Name: Lenumlostat
Brand: TargetMol
SKU: T69913
Price: 197 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T69913 Copy Product Info

Purity: 99.08%

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Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.

Lenumlostat

Copy Product Info

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Catalog No. T69913

Synonyms PAT-1251, GB2064, 2007885-39-2

Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.

Cas No. 2098884-52-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$197	In Stock	In Stock
5 mg	$497	In Stock	In Stock
10 mg	$747	In Stock	In Stock
25 mg	$1,490	In Stock	In Stock
50 mg	$2,320	In Stock	In Stock
100 mg	$3,320	In Stock	In Stock
500 mg	$6,670	-	In Stock
1 mL x 10 mM (in DMSO)	$547	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.08%

ee:100%

Appearance:Solid

Color:White

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COA LCMS CSFC FNMR HNMR

Product Introduction

Bioactivity

Description	Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.
Targets&IC50	LOXL2:0.10 μM (Mouse), LOXL2:0.12 μM (Rat), LOXL2:0.16 μM (Dog), LOXL3 (human):1.17 μM, LOXL2 (human):0.71 μM
In vitro	Lenumlostat(PAT-1251)is a Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 μM and 1.17 μM for hLOXL2 and hLOXL3, respectively. It also potently inhibits LOXL2 in mouse, rat, and dog, with IC50s of 0.10 μM, 0.12 μM, and 0.16 μM, respectively. Lenumlostat(PAT-1251) exhibits high selectivity for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO). Additionally, it shows selectivity against the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with less than 10% inhibition at 10 μM[1].
Synonyms	PAT-1251, GB2064, 2007885-39-2

Chemical Properties

Molecular Weight	399.34
Formula	C₁₈H₁₇F₄N₃O₃
Cas No.	2098884-52-5
Smiles	O(C=1N=C(C(F)(F)F)C=C(CN)C1)C2=CC(C(=O)N3C[C@@H](F)[C@H](O)C3)=CC=C2

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (112.69 mM), Sonication is recommended.

H2O: 80 mg/mL (200.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5041 mL	12.5207 mL	25.0413 mL	125.2066 mL
5 mM	0.5008 mL	2.5041 mL	5.0083 mL	25.0413 mL
10 mM	0.2504 mL	1.2521 mL	2.5041 mL	12.5207 mL
20 mM	0.1252 mL	0.6260 mL	1.2521 mL	6.2603 mL
50 mM	0.0501 mL	0.2504 mL	0.5008 mL	2.5041 mL
100 mM	0.0250 mL	0.1252 mL	0.2504 mL	1.2521 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc