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Poloxamer 188

Name: Poloxamer 188
Brand: TargetMol
SKU: T40802
Rating: 4.5 (1 reviews)

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Catalog No. T40802Cas No. 691397-13-4

Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice.

Poloxamer 188

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Catalog No. T40802Cas No. 691397-13-4

Pack Size	Price	Availability	Quantity
50 mg	Inquiry	Backorder
100 mg	Inquiry	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Poloxamer 188 is a nonionic triblock copolymer surfactant and bioactive excipient used as a medical excipient to exacerbate cerebral amyloidosis, presynaptic dystrophy, and pathogenic microglial cell activation in 5XFAD mice.
In vitro	Poloxamer 188 exhibited a protective effect on mouse brain microvascular endothelial cells (MBEC) after treatment in the concentration range of 10-1000 μM for 5 hours. In addition, Docetaxel-loaded PLGA/Poloxamer 188 nanoparticles significantly increased drug uptake levels and cytotoxicity in Docetaxel-resistant MCF-7 TAX30 human breast cancer cells compared to Docetaxel-loaded PLGA nanoparticles. [1][2]
In vivo	Poloxamer 188 administered intravenously at a dose of 150 mg/kg over 240 minutes significantly reduced muscle edema and lipid peroxidation induced by ischemia-reperfusion. [3]

Chemical Properties

Cas No.

691397-13-4

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Poloxamer 188