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Trimethoprim lactate

Name: Trimethoprim lactate
Brand: TargetMol
SKU: T39862
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39862Cas No. 23256-42-0

Alias Primsol lactate, NSC-106568 lactate, NIH204 lactate, NIH 204 lactate, BW56-72 lactate, BW 56-72 lactate

Trimethoprim lactate (NSC-106568 lactate) is an antibiotic that inhibits bacterial dihydrofolate reductase (DHFR). Trimethoprim lactate has demonstrated antimicrobial activity, with excellent inhibition of Gramnegative bacteria. Trimethoprim lactate is used alone for the Trimethoprim lactate is used alone or in combination with other antibiotics to treat a variety of eye, lung, and gastrointestinal infections.

Trimethoprim lactate

🥰Excellent

Purity: 99.9%

Catalog No. T39862Alias Primsol lactate, NSC-106568 lactate, NIH204 lactate, NIH 204 lactate, BW56-72 lactate, BW 56-72 lactateCas No. 23256-42-0

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$42	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Trimethoprim lactate (NSC-106568 lactate) is an antibiotic that inhibits bacterial dihydrofolate reductase (DHFR). Trimethoprim lactate has demonstrated antimicrobial activity, with excellent inhibition of Gramnegative bacteria. Trimethoprim lactate is used alone for the Trimethoprim lactate is used alone or in combination with other antibiotics to treat a variety of eye, lung, and gastrointestinal infections.
In vitro	Trimethoprim lactate interferes with folate metabolism by inhibiting dihydrofolate reductase (DHFR) activity, thereby preventing the reduction of dihydrofolate to tetrahydrofolate (THF). In E. coli cells, Trimethoprim lactate causes protein aggregation and induces major heat shock proteins (Hsps), suggesting that its presence leads to protein misfolding.Trimethoprim lactate induces the expression of the heat shock proteins DnaK, DnaJ, GroEL, ClpB, and IbpA/B, of which IbpA/B was most significantly induced and co-aggregated with insoluble proteins. [1]
In vivo	In an intraperitoneal infection assay in mice, the CD50 values of Trimethoprim lactate against Haemophilus influenzae, Streptococcus pneumoniae, Escherichia coli, and Neisseria meningitidis were 150 mg/kg, 335 mg/kg, 27.5 mg/kg, and 8.4 mg/kg, respectively. When conjugated with thiomaltose (TM-TMP), Trimethoprim lactate maintains stability in complete serum, with a half-life of approximately one hour, and shows an MIC of about 1 μM against E. coli [2].
Synonyms	Primsol lactate, NSC-106568 lactate, NIH204 lactate, NIH 204 lactate, BW56-72 lactate, BW 56-72 lactate

Chemical Properties

Molecular Weight	380.4
Formula	C₁₇H₂₄N₄O₆
Cas No.	23256-42-0
Smiles	O=C(O)C(O)C.N=1C=C(C(=NC1N)N)CC2=CC(OC)=C(OC)C(OC)=C2

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (525.76 mM), Sonication is recommended.

H2O: 10 mg/mL (26.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6288 mL	13.1441 mL	26.2881 mL	131.4406 mL
5 mM	0.5258 mL	2.6288 mL	5.2576 mL	26.2881 mL
10 mM	0.2629 mL	1.3144 mL	2.6288 mL	13.1441 mL
20 mM	0.1314 mL	0.6572 mL	1.3144 mL	6.5720 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6288 mL
100 mM	0.0263 mL	0.1314 mL	0.2629 mL	1.3144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc