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DG172 dihydrochloride

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Catalog No. T7821Cas No. 1361504-77-9
Alias DG-172 dihydrochloride, DG172 (dihydrochloride)

DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).

DG172 dihydrochloride

DG172 dihydrochloride

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🥰Excellent
Purity: 99.87%
Catalog No. T7821Alias DG-172 dihydrochloride, DG172 (dihydrochloride)Cas No. 1361504-77-9
DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$34In StockIn Stock
5 mg$55In StockIn Stock
10 mg$97In StockIn Stock
25 mg$197In StockIn Stock
50 mg$322In StockIn Stock
100 mg$522In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.87%
Appearance:Solid
Color:White
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
Targets&IC50
PPARβ/δ:27 nM
In vitro
DG172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC(50) = 27 nM) and potent inverse agonistic properties.?DG172 selectively inhibited the agonist-induced activity of PPARβ/δ, enhanced transcriptional corepressor recruitment, and down-regulated transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC(50) = 9.5 nM).?Importantly, DG172 was bioavailable after oral application to mice with peak plasma levels in the concentration range of its maximal inhibitory potency, suggesting that 37 will be an invaluable tool to elucidate the functions and therapeutic potential of PPARβ/δ[1].
SynonymsDG-172 dihydrochloride, DG172 (dihydrochloride)
Chemical Properties
Molecular Weight455.2
FormulaC20H22BrCl2N3
Cas No.1361504-77-9
SmilesCl.Cl.CN1CCN(CC1)c1ccc(\C=C(/C#N)c2ccccc2Br)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 14.29 mg/mL (31.39 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.1968 mL10.9842 mL21.9684 mL109.8418 mL
5 mM0.4394 mL2.1968 mL4.3937 mL21.9684 mL
10 mM0.2197 mL1.0984 mL2.1968 mL10.9842 mL
20 mM0.1098 mL0.5492 mL1.0984 mL5.4921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PPARPeroxisome proliferator-activated receptorsInhibitorinhibitDG-172 DihydrochlorideDG172 dihydrochlorideDG-172DG172DG 172 DihydrochlorideDG 172
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