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(S)-Roscovitine (Alias: (S)-Seliciclib, (S)-CYC202)

Name: (S)-Roscovitine
Brand: TargetMol
SKU: T88822
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T88822 Copy Product Info

Purity: 99.39%

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(S)-Roscovitine is a potent, selective CDK inhibitor (CDK2/CyclinE IC50 = 0.7 μM). It induces apoptosis by blocking cell cycle progression, utilized for cancer and inflammatory disease research.

(S)-Roscovitine

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🥰Excellent

Catalog No. T88822

Alias (S)-Seliciclib, (S)-CYC202

(S)-Roscovitine is a potent, selective CDK inhibitor (CDK2/CyclinE IC50 = 0.7 μM). It induces apoptosis by blocking cell cycle progression, utilized for cancer and inflammatory disease research.

Cas No. 186692-45-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$106	-	In Stock
25 mg	$213	-	In Stock
50 mg	$347	-	In Stock
1 mL x 10 mM (in DMSO)	$71	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.39%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	(S)-Roscovitine is a potent, selective CDK inhibitor (CDK2/CyclinE IC50 = 0.7 μM). It induces apoptosis by blocking cell cycle progression, utilized for cancer and inflammatory disease research.
Targets&IC50	CDK7:≤1 μM, CDK2:≤1 μM, CDK5:≤1 μM, CDK9:≤1 μM, CDK1:≤1 μM
In vivo	(S)-Roscovitine (25 mg/kg i.p.) reduces total infarct volume and inhibits aberrant CDK5 activity in cerebral ischemia models [1][2].
Synonyms	(S)-Seliciclib, (S)-CYC202

Chemical Properties

Molecular Weight	354.45
Formula	C₁₉H₂₆N₆O
Cas No.	186692-45-5
Smiles	C(C)(C)N1C=2C(=C(NCC3=CC=CC=C3)N=C(N[C@@H](CC)CO)N2)N=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (112.85 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8213 mL	14.1064 mL	28.2127 mL	141.0636 mL
5 mM	0.5643 mL	2.8213 mL	5.6425 mL	28.2127 mL
10 mM	0.2821 mL	1.4106 mL	2.8213 mL	14.1064 mL
20 mM	0.1411 mL	0.7053 mL	1.4106 mL	7.0532 mL
50 mM	0.0564 mL	0.2821 mL	0.5643 mL	2.8213 mL
100 mM	0.0282 mL	0.1411 mL	0.2821 mL	1.4106 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc