Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR with Ki of 0.18 µM. GABAA receptor agent 4 has immunomodulatory potential which was shown to efficiently rescue the inhibition of T cell proliferation [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | GABAA receptor agent 4 (compound 1e) is a potent antagonist of γ-GABAAR with Ki of 0.18 µM. GABAA receptor agent 4 has immunomodulatory potential which was shown to efficiently rescue the inhibition of T cell proliferation [1]. |
In vitro | Compound 1e, a GABAA receptor antagonist, exhibits varying inhibitory concentrations (IC50s) across subtypes: 4.95 μM (α1β2δ), 0.195 μM (α4β1δ), 0.250 μM (α4β2δ), 1.95 μM (α6β2δ), 2.18 μM (α1β2γ2), 7.56 μM (α2β2γ2), 0.56 μM (α3β2γ2), and 0.54 μM (α5β2γ2) [1]. Additionally, at a concentration of 50 μM over 96 hours, Compound 1e counteracts alprazolam-induced proliferation inhibition in both human PBMC and mouse splenocyte populations, demonstrating minimal cellular toxicity [1]. |
Molecular Weight | 272.39 |
Formula | C17H24N2O |
CAS No. | 2035203-91-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GABAA receptor agent 4 2035203-91-7 inhibitor inhibit