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Anti-TERF1 Antibody (3H363)

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Catalog No. TMAB-13454

Anti-TERF1 Antibody (3H363) is a Rabbit antibody targeting TERF1. Anti-TERF1 Antibody (3H363) can be used in WB,ICC/IF.

Anti-TERF1 Antibody (3H363)

Anti-TERF1 Antibody (3H363)

Copy Product Info
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Catalog No. TMAB-13454
Anti-TERF1 Antibody (3H363) is a Rabbit antibody targeting TERF1. Anti-TERF1 Antibody (3H363) can be used in WB,ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1487-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-TERF1 Antibody (3H363) is a Rabbit antibody targeting TERF1. Anti-TERF1 Antibody (3H363) can be used in WB,ICC/IF.
Ig Type
IgG
Clone
3H363
Reactivity
Human (predicted:Mouse)
Verified Activity
25 μg total protein per lane of various lysates (see on figure) probed with TERF1 monoclonal antibody, unconjugated (TMAB-13454) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.
Application
WB
ICC/IF
Recommended Dose
WB: 1:500-2000; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus. Cytoplasm; cytoskeleton; spindle. Chromosome; telomere. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.
Tissue SpecificityHighly expressed and ubiquitous. Isoform Pin2 predominates.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundPlays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression.
Antigen Details
Immunogen
A synthesized peptide: human TERF1
Antigen Species
Human
Gene Name
TERF1
Gene ID
7013
Protein Name
Telomeric repeat-binding factor 1
Uniprot ID
P54274
Function
Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Chemical Properties
Molecular WeightTheoretical: 50 kDa. Actual: 50 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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