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Anti-TERF1 Antibody (3H363)
Catalog No. TMAB-13454 Copy Product Info
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Anti-TERF1 Antibody (3H363) is a Rabbit antibody targeting TERF1. Anti-TERF1 Antibody (3H363) can be used in WB,ICC/IF.
Anti-TERF1 Antibody (3H363)
Copy Product Info🥰Excellent
Catalog No. TMAB-13454
Anti-TERF1 Antibody (3H363) is a Rabbit antibody targeting TERF1. Anti-TERF1 Antibody (3H363) can be used in WB,ICC/IF.
Anti-TERF1 Antibody
(3H363)
(3H363)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-TERF1 Antibody (3H363) is a Rabbit antibody targeting TERF1. Anti-TERF1 Antibody (3H363) can be used in WB,ICC/IF. |
| Ig Type | IgG |
| Clone | 3H363 |
| Reactivity | Human (predicted:Mouse) |
| Verified Activity | 25 μg total protein per lane of various lysates (see on figure) probed with TERF1 monoclonal antibody, unconjugated (TMAB-13454) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm; cytoskeleton; spindle. Chromosome; telomere. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle. |
| Tissue Specificity | Highly expressed and ubiquitous. Isoform Pin2 predominates. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. |
| Immunogen | A synthesized peptide: human TERF1 |
| Antigen Species | Human |
| Gene Name | TERF1 |
| Gene ID | |
| Protein Name | Telomeric repeat-binding factor 1 |
| Uniprot ID | |
| Function | Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. |
| Molecular Weight | Theoretical: 50 kDa. Actual: 58 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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