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GlyT1 Inhibitor 1

Name: GlyT1 Inhibitor 1
Brand: TargetMol
SKU: T11435
Rating: 4.5 (1 reviews)

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Catalog No. T11435Cas No. 1820934-93-7

GlyT1 Inhibitor 1 is a selective and potent GlyT1 inhibitor, inhibiting rGlyT1, used in research on neurological disorders.

GlyT1 Inhibitor 1

😃Good

Catalog No. T11435Cas No. 1820934-93-7

GlyT1 Inhibitor 1 is a selective and potent GlyT1 inhibitor, inhibiting rGlyT1, used in research on neurological disorders.

Pack Size	Price	Availability
25 mg	$1,400	6-8 weeks
50 mg	$1,820	6-8 weeks
100 mg	$2,500	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GlyT1 Inhibitor 1 is a selective and potent GlyT1 inhibitor, inhibiting rGlyT1, used in research on neurological disorders.
Targets&IC50	GlyT1 (rat):38 nM
In vitro	GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor that inhibits rGlyT1 with an IC50 of 38 nM. [1]
In vivo	Increase of GlyT1 Inhibitor 1 (10 mg/kg, oral) in cerebrospinal fluid (CSF) of rats. [1]

Chemical Properties

Molecular Weight	387.43
Formula	C₂₂H₂₁N₅O₂
Cas No.	1820934-93-7
Smiles	N#CC1=CC=C(OC(C)C)C(=C1)C(=O)N2CC3=NN(C=C3C2)C=4C=CN=C(C4)C
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (51.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5811 mL	12.9056 mL	25.8111 mL	129.0556 mL
5 mM	0.5162 mL	2.5811 mL	5.1622 mL	25.8111 mL
10 mM	0.2581 mL	1.2906 mL	2.5811 mL	12.9056 mL
20 mM	0.1291 mL	0.6453 mL	1.2906 mL	6.4528 mL
50 mM	0.0516 mL	0.2581 mL	0.5162 mL	2.5811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc