Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Moexiprilat, an active metabolite of the prodrug moexipril formed through side chain ester hydrolysis in vivo, functions as an angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) inhibitor. At a concentration of 10 nM, it inhibits the proliferation of primary neonatal rat cardiac fibroblasts stimulated by estrone or angiotensin II. Furthermore, when given at a daily dosage of 50 mg/kg, moexiprilat reduces mean arterial blood pressure and elevates levels of atrial natriuretic peptide, an indicator of hypertension, in ovariectomized mice.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 853.00 | |
10 mg | 35 days | $ 1,590.00 |
Description | Moexiprilat, an active metabolite of the prodrug moexipril formed through side chain ester hydrolysis in vivo, functions as an angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) inhibitor. At a concentration of 10 nM, it inhibits the proliferation of primary neonatal rat cardiac fibroblasts stimulated by estrone or angiotensin II. Furthermore, when given at a daily dosage of 50 mg/kg, moexiprilat reduces mean arterial blood pressure and elevates levels of atrial natriuretic peptide, an indicator of hypertension, in ovariectomized mice. |
Synonyms | RS 10029 |
Molecular Weight | 470.51 |
Formula | C25H30N2O7 |
CAS No. | 103775-14-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: soluble
DMSO: soluble
Ethanol: soluble
You can also refer to dose conversion for different animals. More
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Moexiprilat 103775-14-0 RS 10029 inhibitor inhibit