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Prochloraz
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Catalog No. T20625Cas No. 67747-09-5
Alias Sporgon, Prelude
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).
Prochloraz
Copy Product Info🥰Excellent
Purity: 99.79%
Catalog No. T20625Alias Sporgon, PreludeCas No. 67747-09-5
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $34 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.79%
Appearance:Solid
Color:Yellow
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Product Introduction
Prochloraz AI Summary
Prochloraz demonstrates broad-spectrum fungicidal activity against various fungi, including both tebuconazole-adapted and nonadapted wild type Colletotrichum graminicola strains, Fusarium culmorum, Fusarium oxysporum, Macrophomina phaseolina, Oculimacula yallundae, Phytophthora cactorum, Alternaria alternata, Diplodia mutila, Neofusicoccum luteum, Zymoseptoria tritici, and Monilinia laxa. It exhibits potent inhibitory effects on mycelial growth and disease incidence with varying EC50 and MIC values depending on the fungal species and environmental conditions.
The compound also affects multiple signaling pathways, acting as an agonist or antagonist for androgen receptor, farnesoid X receptor, thyroid hormone receptor beta, peroxisome proliferator-activated receptor (delta and gamma), estrogen receptor alpha, aryl hydrocarbon receptor (AhR), p53 signaling pathway, antioxidant response element (ARE) signaling pathway, and pregnane X receptor (both rat and human). These bioactivities indicate its potential to interact with diverse biological targets, making it a versatile agent for controlling fungal infections and potentially other applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM). |
| Targets&IC50 | Antifungal:40 nM, ERR:25 μM, AhR:1 μM(EC50), Androgen receptor:4 μM |
| Synonyms | Sporgon, Prelude |
| Molecular Weight | 376.67 |
| Formula | C15H16Cl3N3O2 |
| Cas No. | 67747-09-5 |
| Smiles | C(N(CCOC1=C(Cl)C=C(Cl)C=C1Cl)CCC)(=O)N2C=CN=C2 |
| Relative Density. | 1.405 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (663.71 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.65 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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