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Pimecrolimus

Name: Pimecrolimus
Brand: TargetMol
SKU: T2648
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2648Cas No. 137071-32-0

Alias SDZ-ASM 981, ASM 981

Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.

Pimecrolimus

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Purity: 99.87%

Catalog No. T2648Alias SDZ-ASM 981, ASM 981Cas No. 137071-32-0

Pack Size	Price	Availability
10 mg	$31	In Stock
25 mg	$48	In Stock
50 mg	$70	In Stock
100 mg	$98	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock

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Purity:99.87%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.
In vitro	Pimecrolimus effectively alleviates allergic symptoms in a variety of (allergic) animals. Within the context of both the acute allergic dermatitis low-magnesium hairless rat model and the moderate allergic contact dermatitis mouse model, Pimecrolimus inhibits inflammatory responses and pruritic (itching) symptoms.
In vivo	In mast cells, Pimecrolimus inhibits the transcription and synthesis of cytokines, while simultaneously promoting the release of 5-hydroxytryptamine and β-hexosaminidase. In T lymphocytes, Pimecrolimus suppresses activation by inhibiting phosphatase activity, thereby blocking T-cell activation.
Synonyms	SDZ-ASM 981, ASM 981

Chemical Properties

Molecular Weight	810.45
Formula	C₄₃H₆₈ClNO₁₁
Cas No.	137071-32-0
Smiles	[H][C@]12O[C@](O)([C@H](C)C[C@@H]1OC)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])([C@H](C)[C@@H](O)CC(=O)[C@H](CC)\C=C(C)\C[C@H](C)C[C@@H]2OC)C(\C)=C\[C@@H]1CC[C@H](Cl)[C@@H](C1)OC
Relative Density.	1.19
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (114.75 mM), Sonication is recommended.

DMSO: 93 mg/mL (114.75 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2339 mL	6.1694 mL	12.3388 mL	61.6941 mL
5 mM	0.2468 mL	1.2339 mL	2.4678 mL	12.3388 mL
10 mM	0.1234 mL	0.6169 mL	1.2339 mL	6.1694 mL
20 mM	0.0617 mL	0.3085 mL	0.6169 mL	3.0847 mL
50 mM	0.0247 mL	0.1234 mL	0.2468 mL	1.2339 mL
100 mM	0.0123 mL	0.0617 mL	0.1234 mL	0.6169 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc