store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 58.00 | |
5 mg | In stock | $ 139.00 | |
10 mg | In stock | $ 255.00 | |
25 mg | In stock | $ 513.00 | |
50 mg | In stock | $ 728.00 | |
100 mg | In stock | $ 985.00 | |
500 mg | In stock | $ 1,970.00 |
Description | SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response. |
In vitro | SRI-42127 (0.05-1 μM; 24 h) inhibits HuR translocation in LPS-activated glial cells in vitro and significantly attenuates the production of pro-inflammatory mediators, including IL1β, IL-6, TNF-α, iNOS, CXCL1 and CCL2[1]. |
In vivo | SRI-42127 (15 mg/kg; intraperitoneal injection; single dose) inhibits in vivo microglial activation and attenuates neutrophil and monocyte recruitment/chemotaxis[1]. |
Molecular Weight | 348.4 |
Formula | C19H20N6O |
CAS No. | 2727872-68-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (86.11 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SRI-42127 2727872-68-4 Chromatin/Epigenetic HuR inhibitor inhibit