Shopping Cart

Remove All
Your shopping cart is currently empty

ML-099

Name: ML-099
Brand: TargetMol
SKU: T22991
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22991Cas No. 496775-95-2

ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.

ML-099

🥰Excellent

Purity: 99.73%

Catalog No. T22991Cas No. 496775-95-2

ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.

Pack Size	Price	Availability
1 mg	$41	In Stock
2 mg	$58	In Stock
5 mg	$97	In Stock
10 mg	$155	In Stock
25 mg	$322	In Stock
50 mg	$513	In Stock
100 mg	$747	In Stock
1 mL x 10 mM (in DMSO)	$95	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.
Targets&IC50	Cell division cycle 42:100 nM(wild type,EC50), Cell division cycle 42:58.88 nM(activated mutant,EC50), Rac1:25.42 nM(activated mutant,EC50), Ras:95.5 nM(activated mutant,EC50), Rac1:20.17 nM(wild type,EC50)
In vitro	ML-099 activates Ras protein wild type(EC50 = 141.25 nM), Rab7(EC50 = 181.97 nM), Rab-2A(EC50 = 354.81 nM), Rac1 protein activated mutant(EC50 = 25.42 nM), Rac1 protein wild type(EC50 = 20.17 nM), Ras protein activated mutant(EC50 = 95.5 nM), cell division cycle 42 activated mutant(EC50 = 58.88 nM) and cell division cycle 42 wild type(EC50 = 100 nM)[1].

Chemical Properties

Molecular Weight	259.32
Formula	C₁₄H₁₃NO₂S
Cas No.	496775-95-2
Smiles	OC(=O)c1cccnc1SCCc1ccccc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (192.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8562 mL	19.2812 mL	38.5624 mL	192.8120 mL
5 mM	0.7712 mL	3.8562 mL	7.7125 mL	38.5624 mL
10 mM	0.3856 mL	1.9281 mL	3.8562 mL	19.2812 mL
20 mM	0.1928 mL	0.9641 mL	1.9281 mL	9.6406 mL
50 mM	0.0771 mL	0.3856 mL	0.7712 mL	3.8562 mL
100 mM	0.0386 mL	0.1928 mL	0.3856 mL	1.9281 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc