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Maresin 1
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Catalog No. T38047Cas No. 1268720-28-0
Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion.
Maresin 1
Copy Product Info😃Good
Catalog No. T38047Cas No. 1268720-28-0
Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 μg (277.4 µM * 100 μL in Ethanol) | $193 | 3-6 months | 3-6 months | |
| 25 μg (277.4 µM * 250 μL in Ethanol) | $450 | 3-6 months | 3-6 months | |
| 50 μg (277.4 µM * 500 μL in Ethanol) | $850 | 3-6 months | 3-6 months | |
| 100 μg (277.4 µM * 1 mL in Ethanol) | $1,500 | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion. |
| In vitro | In addition to reducing the production of IL-1β, TNF-α, IL-6, and INF-γ, Maresin 1 (MaR1, 300 nM) also diminishes neutrophil migration and the generation of reactive oxygen species [2]. |
| In vivo | In a dose-dependent manner, Maresin 1 (MaR1) inhibits TRPV1 currents in neurons, blocking capsaicin-induced inward currents (IC50=0.49 nM), and alleviates inflammation and chemotherapy-induced neuropathic pain in mice [3].Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, iv) protects mice from acute DSS-induced colitis. Treatment with Maresin 1 (0.3 and 1 μg/animal, iv) significantly reduces macroscopic damage in the acute phase of DSS-induced colitis [2]. |
| Molecular Weight | 360.49 |
| Formula | C22H32O4 |
| Cas No. | 1268720-28-0 |
| Smiles | [C@H](/C=C/C=C/C=C\[C@H](C/C=C\C/C=C\CC)O)(C/C=C\CCC(O)=O)O |
| Relative Density. | 1.048 g/cm3 (Predicted) |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF: 50 mg/mL (138.7 mM), Sonication is recommended. PBS (pH 7.2): 0.05 mg/mL (0.14 mM), Sonication is recommended. Ethanol: 40 mg/mL (110.96 mM), Sonication is recommended. DMSO: 40 mg/mL (110.96 mM), Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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