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Maresin 1

Catalog No. T38047 CAS 1268720-28-0

Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion.

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Maresin 1, CAS 1268720-28-0

Pack Size	Availability	Price/USD
10 μg	35 days	$ 193.00
25 μg	35 days	$ 450.00
50 μg	35 days	$ 850.00
100 μg	35 days	$ 1,500.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion.
In vitro	In addition to reducing the production of IL-1β, TNF-α, IL-6, and INF-γ, Maresin 1 (MaR1, 300 nM) also diminishes neutrophil migration and the generation of reactive oxygen species [2].
In vivo	In a dose-dependent manner, Maresin 1 (MaR1) inhibits TRPV1 currents in neurons, blocking capsaicin-induced inward currents (IC50=0.49 nM), and alleviates inflammation and chemotherapy-induced neuropathic pain in mice [3].Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, iv) protects mice from acute DSS-induced colitis. Treatment with Maresin 1 (0.3 and 1 μg/animal, iv) significantly reduces macroscopic damage in the acute phase of DSS-induced colitis [2].

Molecular Weight	360.49
Formula	C22H32O4
CAS No.	1268720-28-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 50 mg/mL

PBS (pH 7.2): 0.05 mg/mL

Ethanol: 40 mg/mL(110.95 mM), Sonication is recommended.

DMSO: 40 mg/mL(110.95 mM), Sonication is recommended.

References and Literature

1. Olsen MV,et al. Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells. J Cell Physiol. 2021 Jan;236(1):340-353. 2. Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191(8):4288-98. 3. Serhan CN, et al. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J. 2012 Apr;26(4):1755-65. 4. Serhan, C. . (2007).

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Keywords

Maresin 1 1268720-28-0 Membrane transporter/Ion channel Metabolism Calcium Channel inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.