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TAT-DEF-Elk-1

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Catalog No. TP2157Cas No. 1220751-16-5
Alias TDE

TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.

TAT-DEF-Elk-1
Other Forms of TAT-DEF-Elk-1:

TAT-DEF-Elk-1

😃Good
Catalog No. TP2157Alias TDECas No. 1220751-16-5
TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.
Targets&IC50
ELK1:
In vitro
Elk-1 phosphorylation on Ser383/389 simultaneously induces Elk-1 nuclear translocation and SRE-dependent gene expression. TAT-DEF-Elk-1 (5 μM for 2 hours) significantly inhibits c-Fos, Zif268, and JunB without affecting c-Jun expression. Additionally, TAT-DEF-Elk-1 (5-10 μM for 1 hour) specifically inhibits glutamate-induced Elk-1 activation without interfering with ERK, MSK-1, or CREB phosphorylation [1].
In vivo
TAT-DEF-Elk-1 (i.p.; 1mg/kg; daily; 14 days) reflects antidepressant efficacy in mice, it decreases immobility similar to the antidepressant desipramine and fluoxetine [2].
SynonymsTDE
Chemical Properties
Molecular Weight3561.136
FormulaC155H259N57O40
Cas No.1220751-16-5
Relative Density.1.53 g/cm3 (Predicted)
Sequence ShortGRKKRRQRRRPPSPAKLSFQFPSSGSAQVHI
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TAT-DEF-Elk-1TATDEFElk1TAT DEF Elk 1Elk-1
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