Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 110.00 | |
5 mg | 35 days | $ 483.00 | |
10 mg | 35 days | $ 853.00 | |
25 mg | 35 days | $ 1,860.00 |
Description | ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively). |
Molecular Weight | 373.83 |
Formula | C16H24ClN3O5 |
CAS No. | 1502027-70-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL
DMF: 30 mg/mL
Ethanol: Slightly soluble
DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ARN14988 1502027-70-4 ARN 14988 ARN-14988 inhibitor inhibit