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BAY-3827

Catalog No. T73350 CAS 2377576-35-5

BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer model. BAY-3827 inhibits the phosphorylation of acetyl CoA carboxylase 1.

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BAY-3827, CAS 2377576-35-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 372.00
50 mg	In stock	$ 622.00
100 mg	In stock	$ 879.00
500 mg	In stock	$ 1,750.00
1 mL * 10 mM (in DMSO)	In stock	$ 126.00

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Purity: 100%

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Description	BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer model. BAY-3827 inhibits the phosphorylation of acetyl CoA carboxylase 1.
Targets&IC50	Aurora A:1324 nM, c-Met:788 nM, Rsk4:36 nM, AMPK, 2 mM ATP:15 nM, AMPK,10 µM ATP:1.4 nM, Flt3:124 nM
In vitro	BAY-3827, in the concentration range of 0-200 μM, inhibits AMPK kinase activity with IC50 values of 1.4 nM at low ATP concentration (10 µM) and 15 nM at high ATP concentration (2 mM)[1].In the concentration range of 0-200 μM, BAY-3827 inhibits Aurora A, Flt3, c-Met, and Rsk4 with IC50 values of 1324, 124, 788, and 36 nM, respectively, at 10 µM ATP concentration[1].After overnight treatment, BAY-3827 strongly reduces ACC1 Ser79 phosphorylation in LNCaP and VCaP cells, with a lesser extent in IMR-32 and especially in Colo320 cells[1].At concentrations of 0-10 nM over 6 days, BAY-3827 exhibits strong inhibitory effects on LNCaP and VCaP cells[1].At concentrations of 1 and 5 μM over 24 and 48 hours, BAY-3827 represses LIPE gene expression, reduces serine/threonine kinase AKT3, and blocks the expression of several genes from the mitochondrial carnitine palmitoyltransferase (CPT) family, which is involved in acyl carnitine formation in VCaP cells[1]. At a concentration of 5 μM over 2-4 days, BAY-3827 significantly increases the formation of lipid droplets compared to androgen treatment only[1].

Molecular Weight	468.53
Formula	C27H25FN6O
CAS No.	2377576-35-5

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keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (42.69 mM), Sonication is recommended.

References and Literature

1. Lemos C, et al. The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models. Cell Oncol (Dordr). 2021 Jun;44(3):581-594.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Immunology/Inflammation Compound Library

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Keywords

BAY-3827 2377576-35-5 Chromatin/Epigenetic Metabolism PI3K/Akt/mTOR signaling Acyltransferase AMPK inhibitor inhibit

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