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HPI 1

Name: HPI 1
Brand: TargetMol
SKU: T22089
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22089Cas No. 599150-20-6

HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).

HPI 1

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Purity: 97.6%

Catalog No. T22089Cas No. 599150-20-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$55	In Stock	In Stock
5 mg	$93	In Stock	In Stock
10 mg	$137	In Stock	In Stock
25 mg	$229	In Stock	In Stock
50 mg	$342	In Stock	In Stock
100 mg	$497	-	In Stock
500 mg	$1,080	-	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.6%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

HPI 1 AI Summary

HPI 1 has demonstrated antagonist activity at the hedgehog receptor with an IC50 of 1500.0 nM. It has also shown inhibition of SAG-induced hedgehog pathway in mouse SHH-LIGHT2 cells, indicating potential bioactivity with an IC50 value of less than 10,000.0 nM. Moreover, HPI 1 has been profiled in a PubChem BioAssay for its ability to inhibit Plasmodium falciparum (DD2) proliferation, with a potency of 4727.7 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).
Targets&IC50	SAG:1.5μM, Shh:1.5μM, GLI2:4μM

Chemical Properties

Molecular Weight	463.52
Formula	C₂₇H₂₉NO₆
Cas No.	599150-20-6
Smiles	COCCOC(=O)C1C(C2=CC(O)=CC=C2)C2=C(CC(CC2=O)C2=C(OC)C=CC=C2)N=C1C
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (140.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1574 mL	10.7870 mL	21.5740 mL	107.8702 mL
5 mM	0.4315 mL	2.1574 mL	4.3148 mL	21.5740 mL
10 mM	0.2157 mL	1.0787 mL	2.1574 mL	10.7870 mL
20 mM	0.1079 mL	0.5394 mL	1.0787 mL	5.3935 mL
50 mM	0.0431 mL	0.2157 mL	0.4315 mL	2.1574 mL
100 mM	0.0216 mL	0.1079 mL	0.2157 mL	1.0787 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc