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HPI 1

🥰Excellent
Catalog No. T22089Cas No. 599150-20-6

HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).

HPI 1
Other Forms of HPI 1:

HPI 1

🥰Excellent
Purity: 97.6%
Catalog No. T22089Cas No. 599150-20-6
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
2 mg$55In StockIn Stock
5 mg$93In StockIn Stock
10 mg$137In StockIn Stock
25 mg$229In StockIn Stock
50 mg$342In StockIn Stock
100 mg$497-In Stock
500 mg$1,080-In Stock
1 mL x 10 mM (in DMSO)$109In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.6%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).
Targets&IC50
GLI2:4μM, SAG:1.5μM, Shh:1.5μM
Chemical Properties
Molecular Weight463.52
FormulaC27H29NO6
Cas No.599150-20-6
SmilesCOCCOC(=O)C1C(C2=CC(O)=CC=C2)C2=C(CC(CC2=O)C2=C(OC)C=CC=C2)N=C1C
Relative Density.1.28 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 65 mg/mL (140.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1574 mL10.7870 mL21.5740 mL107.8702 mL
5 mM0.4315 mL2.1574 mL4.3148 mL21.5740 mL
10 mM0.2157 mL1.0787 mL2.1574 mL10.7870 mL
20 mM0.1079 mL0.5394 mL1.0787 mL5.3935 mL
50 mM0.0431 mL0.2157 mL0.4315 mL2.1574 mL
100 mM0.0216 mL0.1079 mL0.2157 mL1.0787 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

SUM159 cellsSUM149SmoothenedInhibitorinhibitHPI-1HPI1HPI 1HedgehoghedgehogGLI1 mRNAGLI antagonist-1GLI antagonist1GLI antagonist 1Glicolony formationanti-proliferative
Related Tags: buy HPI 1 | purchase HPI 1 | HPI 1 cost | order HPI 1 | HPI 1 chemical structure | HPI 1 formula | HPI 1 molecular weight
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