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Ximoprofen

Name: Ximoprofen
Brand: TargetMol
SKU: T35180
Price: 373 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35180Cas No. 56187-89-4

Alias Ximoprofenum, Ximoprofeno

Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.

Ximoprofen

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Purity: 99.99%

Catalog No. T35180Alias Ximoprofenum, XimoprofenoCas No. 56187-89-4

Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$373	In Stock	In Stock
5 mg	$896	In Stock	In Stock
10 mg	$1,230	In Stock	In Stock
25 mg	$1,820	In Stock	In Stock
50 mg	$2,450	In Stock	In Stock
100 mg	$3,290	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.
In vivo	The aim of the study was to evaluate the efficacy of different daily dosages of Ximoprofen in patients with active ankylosing spondylitis. For 2 weeks 5 parallel groups were studied: placebo and Ximoprofen at 5, 10, 20, and 30 mg daily. Response to treatment was defined as an improvement in pain (VAS 100 mm) of at least 50% during the study. At the end of the study, the percentage of responders was higher in the Ximoprofen groups (54%, 41%, 53%, 56% in the 5, 10, 20, and 30 mg groups, respectively) than in the placebo group (21%). The clearest dose-related effect of Ximoprofen observed occurred after one week of treatment. This study 1/confirms the efficacy of Ximoprofen at a 30 mg daily dosage, 2/shows the persistence of this efficacy at lower dosages, 3/suggests that ankylosing spondylitis is a sensitive and relevant human model to assess NSAIDs at an early stage of clinical evaluation.[1]
Synonyms	Ximoprofenum, Ximoprofeno

Chemical Properties

Molecular Weight	261.32
Formula	C₁₅H₁₉NO₃
Cas No.	56187-89-4
Smiles	N(O)=C1CC(C2=CC=C(C(C(O)=O)C)C=C2)CCC1
Relative Density.	1.22g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (191.34 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8267 mL	19.1336 mL	38.2673 mL	191.3363 mL
5 mM	0.7653 mL	3.8267 mL	7.6535 mL	38.2673 mL
10 mM	0.3827 mL	1.9134 mL	3.8267 mL	19.1336 mL
20 mM	0.1913 mL	0.9567 mL	1.9134 mL	9.5668 mL
50 mM	0.0765 mL	0.3827 mL	0.7653 mL	3.8267 mL
100 mM	0.0383 mL	0.1913 mL	0.3827 mL	1.9134 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc