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Cefsulodin sodium

Name: Cefsulodin sodium
Brand: TargetMol
SKU: T0827
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0827Cas No. 52152-93-9

Alias Sulcephalosporin, Cefsulodine sodium

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

Cefsulodin sodium

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Purity: 99.3%

Catalog No. T0827Alias Sulcephalosporin, Cefsulodine sodiumCas No. 52152-93-9

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$41	In Stock	In Stock
100 mg	$59	In Stock	In Stock
200 mg	$83	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$66	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.3%

Color:Yellow

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Product Introduction

Cefsulodin sodium AI Summary

Cefsulodin sodium exhibits significant bioactivity across a range of biological targets, demonstrating diverse inhibitory effects. It exerts inhibitory activity on human Jumonji Domain Containing 2E (JMJD2E), MLL CXXC domain-DNA interaction, Tyrosyl-DNA Phosphodiesterase (TDP1), Tau fibril formation, DNA Polymerase Beta, and several other molecular targets including enzymes and proteins involved in DNA repair, epigenetic regulation, and cellular transport processes. The compound's potency varies widely, from 199.5 nM to 56234.1 nM, depending on the specific target. Additionally, Cefsulodin sodium shows a high level of inhibition (91.84% and 101.2%) in the sodium fluorescein uptake assay in OATP1B1- and OATP1B3-transfected CHO cells at a concentration of 10 µM, suggesting interference with sodium fluorescein transport. In the context of infectious diseases, Cefsulodin sodium inhibits Mycobacterium tuberculosis PTPB with an IC50 value of 16000.0 nM. It also exhibits trypanocidal activity against Trypanosoma cruzi, the causative agent of Chagas disease, displaying moderate activity against the INC-5 strain (14%) and strong activity against the NINOA strain (87%) at 50 µg/mL, with an LC50 value of 16.6 µg/mL against the NINOA strain. Moreover, Cefsulodin sodium shows activity against SARS-CoV-2 in Vero E6 cells, reducing cell viability with an inhibition index of 0.2889 after 72 hours at a MOI of 0.002, indicating potential antiviral properties. Overall, Cefsulodin sodium is a bioactive molecule with inhibitory effects on a variety of biological targets, making it a notable candidate for further investigation in multiple therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.
Targets&IC50	mPTPB:16 μM
Synonyms	Sulcephalosporin, Cefsulodine sodium

Chemical Properties

Molecular Weight	554.52
Formula	C₂₂H₁₉N₄NaO₈S₂
Cas No.	52152-93-9
Smiles	[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c2ccccc2)S([O-])(=O)=O)C3=O)C([O-])=O)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (99.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8034 mL	9.0168 mL	18.0336 mL	90.1681 mL
5 mM	0.3607 mL	1.8034 mL	3.6067 mL	18.0336 mL
10 mM	0.1803 mL	0.9017 mL	1.8034 mL	9.0168 mL
20 mM	0.0902 mL	0.4508 mL	0.9017 mL	4.5084 mL
50 mM	0.0361 mL	0.1803 mL	0.3607 mL	1.8034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc