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(E)-AG 556

Name: (E)-AG 556
Brand: TargetMol
SKU: T21853
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21853Cas No. 133550-41-1

AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.

(E)-AG 556

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Purity: 99.93%

Catalog No. T21853Cas No. 133550-41-1

AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$59	In Stock	In Stock
50 mg	$91	In Stock	In Stock
100 mg	$146	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

(E)-AG 556 AI Summary

(E)-AG 556 demonstrates broad-spectrum bioactivity across multiple pathways and molecular targets. It exhibits inhibitory activity against the epidermal growth factor receptor (EGFR) with an IC50 of 5011.87 nM and against protein kinase HER-2 with an IC50 of 501187.23 nM. Additionally, it inhibits N-methyl-D-aspartate glutamate receptors 1/2A and 1/2B with an IC50 of 560.0 nM and displays inhibition of FEP receptor and ERBB2 receptor autophosphorylation with IC50 values of 5000.0 nM and greater than 500000.0 nM, respectively. Furthermore, the compound shows bioactivity in catechol-O-methyltransferase activity assays and various mechanisms involving Menin-MLL interaction, RECQ1, JMJD2E, TDP1, tau fibril formation, and lipoxygenases. It possesses antiviral properties, as evidenced by its inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells, showing inhibition rates of 6.02% and 0.14% respectively at 10 uM concentration. It also inhibits the SARS-CoV-2 3CL-Pro protease with 30.19% inhibition at 20µM. Moreover, (E)-AG 556 impacts cytochrome P450 enzymes, Janus kinase 2 mutant JAK2V617F, and exhibits inhibitory effects on human HDAC6 enzyme, with specific inhibition percentages in enzymatic assays using commercial and custom peptide substrates..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.

Chemical Properties

Molecular Weight	336.38
Formula	C₂₀H₂₀N₂O₃
Cas No.	133550-41-1
Smiles	C(=C(/C(NCCCCC1=CC=CC=C1)=O)\C#N)\C2=CC(O)=C(O)C=C2
Relative Density.	1.247g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (148.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9728 mL	14.8641 mL	29.7283 mL	148.6414 mL
5 mM	0.5946 mL	2.9728 mL	5.9457 mL	29.7283 mL
10 mM	0.2973 mL	1.4864 mL	2.9728 mL	14.8641 mL
20 mM	0.1486 mL	0.7432 mL	1.4864 mL	7.4321 mL
50 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9728 mL
100 mM	0.0297 mL	0.1486 mL	0.2973 mL	1.4864 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc