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(E)-AG 556

Name: (E)-AG 556
Brand: TargetMol
SKU: T21853
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21853Cas No. 133550-41-1

AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.

(E)-AG 556

🥰Excellent

Purity: 99.93%

Catalog No. T21853Cas No. 133550-41-1

AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$59	In Stock	In Stock
50 mg	$91	In Stock	In Stock
100 mg	$146	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.

Chemical Properties

Molecular Weight	336.38
Formula	C₂₀H₂₀N₂O₃
Cas No.	133550-41-1
Smiles	C(=C(/C(NCCCCC1=CC=CC=C1)=O)\C#N)\C2=CC(O)=C(O)C=C2
Relative Density.	1.247g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (148.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9728 mL	14.8641 mL	29.7283 mL	148.6414 mL
5 mM	0.5946 mL	2.9728 mL	5.9457 mL	29.7283 mL
10 mM	0.2973 mL	1.4864 mL	2.9728 mL	14.8641 mL
20 mM	0.1486 mL	0.7432 mL	1.4864 mL	7.4321 mL
50 mM	0.0595 mL	0.2973 mL	0.5946 mL	2.9728 mL
100 mM	0.0297 mL	0.1486 mL	0.2973 mL	1.4864 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc