Shopping Cart

Your shopping cart is currently empty

(R)-Terazosin

Name: (R)-Terazosin
Brand: TargetMol
SKU: T12643
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T12643Cas No. 109351-34-0

(R)-Terazosin is an active R-enantiomer of Terazosin and a potent antagonist of α1-adrenoceptor [(α1a, α1b, and α1d-adrenoceptor] with Ki values of 6.51 nM, 1.01 nM, and 1.97 nM, respectively).

(R)-Terazosin

Copy Product Info

😃Good

Purity: 99.79%

Catalog No. T12643Cas No. 109351-34-0

(R)-Terazosin is an active R-enantiomer of Terazosin and a potent antagonist of α1-adrenoceptor [(α1a, α1b, and α1d-adrenoceptor] with Ki values of 6.51 nM, 1.01 nM, and 1.97 nM, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$58	In Stock	In Stock
5 mg	$97	In Stock	In Stock
10 mg	$148	In Stock	In Stock
25 mg	$253	In Stock	In Stock
50 mg	$371	In Stock	In Stock
100 mg	$520	-	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	(R)-Terazosin is an active R-enantiomer of Terazosin and a potent antagonist of α1-adrenoceptor [(α1a, α1b, and α1d-adrenoceptor] with Ki values of 6.51 nM, 1.01 nM, and 1.97 nM, respectively).
Targets&IC50	α1A-adrenoceptor:6.51 nM (Ki), α1D-adrenoceptor:1.97 nM (Ki), α1B-adrenoceptor:1.01 nM (Ki)
In vitro	(R)-Terazosin exhibits low affinity for α2a, α2B, and α2c-adrenoceptors (Ki of 3.85 μM, 0.33 μM, and 0.37 μM, respectively). It may serve as a useful probe for exploring the functional roles of adrenoceptor subtypes in various tissues.
In vivo	(R)-Terazosin demonstrates antagonism at rat atrial α2B receptor (pEC30: 5.69) and at rat vas deferens α1A and α2A receptors (pA2: 7.5 and 5.31, respectively).

Chemical Properties

Molecular Weight	387.43
Formula	C₁₉H₂₅N₅O₄
Cas No.	109351-34-0
Smiles	COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)[C@H]1CCCO1
Relative Density.	1.332 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (141.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5811 mL	12.9056 mL	25.8111 mL	129.0556 mL
5 mM	0.5162 mL	2.5811 mL	5.1622 mL	25.8111 mL
10 mM	0.2581 mL	1.2906 mL	2.5811 mL	12.9056 mL
20 mM	0.1291 mL	0.6453 mL	1.2906 mL	6.4528 mL
50 mM	0.0516 mL	0.2581 mL	0.5162 mL	2.5811 mL
100 mM	0.0258 mL	0.1291 mL	0.2581 mL	1.2906 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

(R)-Terazosin

(R)-Terazosin

Featured Recommendations

Batch Information

Resource Download

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Tech Support

Keywords