Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Litronesib

Name: Litronesib
Brand: TargetMol
SKU: T11859L
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T11859LCas No. 910634-41-2

Alias LY-2523355, KF-89617

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

Litronesib

😃Good

Catalog No. T11859LAlias LY-2523355, KF-89617Cas No. 910634-41-2

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks
100 mg	Inquiry	8-10 weeks	8-10 weeks

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
In vitro	Litronesib (LY2523355) functions as a selective inhibitor of Eg5, promoting cancer cell death by inducing mitotic arrest at a concentration of 25 nM. This process requires the prolonged activation of the spindle-assembly checkpoint (SAC)[1].
In vivo	Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].
Synonyms	LY-2523355, KF-89617

Chemical Properties

Molecular Weight	511.7
Formula	C₂₃H₃₇N₅O₄S₂
Cas No.	910634-41-2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (97.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.89 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9543 mL	9.7714 mL	19.5427 mL	97.7135 mL
5 mM	0.3909 mL	1.9543 mL	3.9085 mL	19.5427 mL
10 mM	0.1954 mL	0.9771 mL	1.9543 mL	9.7714 mL
20 mM	0.0977 mL	0.4886 mL	0.9771 mL	4.8857 mL
50 mM	0.0391 mL	0.1954 mL	0.3909 mL	1.9543 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc