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CBP/p300 ligand 2

Name: CBP/p300 ligand 2
Brand: TargetMol
SKU: T40144
Rating: 4.5 (1 reviews)

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Catalog No. T40144Cas No. 2484741-78-6

CBP/p300 ligand 2 is the target protein ligand for PROTAC dCBP-1, a potent and selective p300/CBP degrader.

CBP/p300 ligand 2

😃Good

Catalog No. T40144Cas No. 2484741-78-6

CBP/p300 ligand 2 is the target protein ligand for PROTAC dCBP-1, a potent and selective p300/CBP degrader.

Pack Size	Price	Availability
1 mg	$165	7-10 days
5 mg	$413	7-10 days
10 mg	$689	7-10 days
25 mg	$1,290	7-10 days
50 mg	$1,730	7-10 days
100 mg	$2,330	7-10 days
1 mL x 10 mM (in DMSO)	$477	7-10 days

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Product Introduction

Bioactivity

Description	CBP/p300 ligand 2 is the target protein ligand for PROTAC dCBP-1, a potent and selective p300/CBP degrader.
In vitro	CBP/p300 ligand 2 was treated with LNCaP prostate cancer cells and was found to be non-toxic to these cells.[1]

Chemical Properties

Molecular Weight	524.61
Formula	C₂₇H₃₄F₂N₈O
Cas No.	2484741-78-6
Smiles	O=C(NC)N1CC=2C(=NN(C2CC1)C3CCNCC3)N4C=5C=C(C(=CC5CCC4)C=6C=NN(C6)C)C(F)F

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 180 mg/mL (343.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9062 mL	9.5309 mL	19.0618 mL	95.3089 mL
5 mM	0.3812 mL	1.9062 mL	3.8124 mL	19.0618 mL
10 mM	0.1906 mL	0.9531 mL	1.9062 mL	9.5309 mL
20 mM	0.0953 mL	0.4765 mL	0.9531 mL	4.7654 mL
50 mM	0.0381 mL	0.1906 mL	0.3812 mL	1.9062 mL
100 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.9531 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc