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Nicergoline

Name: Nicergoline
Brand: TargetMol
SKU: T1132
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1132Cas No. 27848-84-6

Alias Nimergoline, Nicergolinum

Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.

Nicergoline

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Purity: 99.80%

Catalog No. T1132Alias Nimergoline, NicergolinumCas No. 27848-84-6

Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$44	In Stock	In Stock
50 mg	$54	In Stock	In Stock
100 mg	$64	In Stock	In Stock
500 mg	$155	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.80%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Nicergoline AI Summary

Nicergoline exhibits a diverse range of bioactivities across multiple biological pathways and interactions. This includes notable inhibition of Menin-MLL interaction in MLL-related leukemias, Human Jumonji Domain Containing 2E (JMJD2E), Tyrosyl-DNA Phosphodiesterase (TDP1), Tau fibril formation, and the interaction between CBF-beta and RUNX1 for Acute Myeloid Leukemia treatment. Additionally, it demonstrates effects on lipid storage modulation and vitamin D receptor (VDR) inhibition, along with blocking malaria parasite plastid. The compound also shows potential in blocking the entry of the Ebola virus. In CHO cells transfected with OATP1B3 and OATP1B1, Nicergoline inhibits sodium fluorescein uptake significantly, with inhibition percentages of 124.07% and 91.22% at 10 µM, respectively. However, in assays related to SARS-CoV-2, the results are mixed. It shows limited inhibition of cell viability in Vero E6 cells (inhibition index of -0.08213), some antiviral activity in Caco-2 cells with -11.94% inhibition, and a modest hit score of 0.1321 in HRCE cells. It also exhibits 20.38% inhibition of SARS-CoV-2 3CL-Pro protease activity at 20 µM and no inhibition of cytotoxicity in VERO-6 cells. Furthermore, Nicergoline inhibits human HDAC6 activity but with varying results dependent upon the peptide substrate used: -49.11% inhibition with a commercial substrate versus -0.19% with a custom one. It also exhibits selective binding to receptors like DRD1, KCNH2, and SLC6A3, and shows antagonist activity at TBXA2R while acting as an agonist at ADORA3 and HTR2B. This compound is evaluated for inhibiting enzymes such as ACHE, MAOA, and PTGS1, displaying a broad spectrum of bioactivities affecting numerous receptors and enzymes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nicergoline (Nicergolinum) is an ergot derivative used to treat senile dementia and other disorders with vascular origins.
Synonyms	Nimergoline, Nicergolinum

Chemical Properties

Molecular Weight	484.39
Formula	C₂₄H₂₆BrN₃O₃
Cas No.	27848-84-6
Smiles	O(C)[C@@]12C=3C=4C(C[C@]1(N(C)C[C@H](COC(=O)C=5C=C(Br)C=NC5)C2)[H])=CN(C)C4C=CC3
Relative Density.	1.47 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (103.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0645 mL	10.3223 mL	20.6445 mL	103.2226 mL
5 mM	0.4129 mL	2.0645 mL	4.1289 mL	20.6445 mL
10 mM	0.2064 mL	1.0322 mL	2.0645 mL	10.3223 mL
20 mM	0.1032 mL	0.5161 mL	1.0322 mL	5.1611 mL
50 mM	0.0413 mL	0.2064 mL	0.4129 mL	2.0645 mL
100 mM	0.0206 mL	0.1032 mL	0.2064 mL	1.0322 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc