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PKN3-IN-1

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Catalog No. T204631Cas No. 2361545-75-5

PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine-protein kinase N3) and GAK (cyclin G-associated kinase) with an IC50 of 0.014 μM and a Ki of 0.0044 μM. PKN3-IN-1 is a potential tool compound for investigating the cell biology of PKN3 and its role in pancreatic and prostate cancers, as well as T-cell acute lymphoblastic leukemia.

PKN3-IN-1

PKN3-IN-1

😃Good
Catalog No. T204631Cas No. 2361545-75-5
PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine-protein kinase N3) and GAK (cyclin G-associated kinase) with an IC50 of 0.014 μM and a Ki of 0.0044 μM. PKN3-IN-1 is a potential tool compound for investigating the cell biology of PKN3 and its role in pancreatic and prostate cancers, as well as T-cell acute lymphoblastic leukemia.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
PKN3-IN-1 (compound 16) inhibits PKN3 (serine/threonine-protein kinase N3) and GAK (cyclin G-associated kinase) with an IC50 of 0.014 μM and a Ki of 0.0044 μM. PKN3-IN-1 is a potential tool compound for investigating the cell biology of PKN3 and its role in pancreatic and prostate cancers, as well as T-cell acute lymphoblastic leukemia.
In vitro
PKN3-IN-1, at a concentration of 1 μM over 48 hours, inhibits PKN3 in HEK 293 cells with an IC50 of 0.014 μM [1]. Additionally, PKN3-IN-1, at 1 μM over 24 hours, inhibits GAK with a Ki of 0.0044 μM in the same cell line [2]. At 1.3 μM, PKN3-IN-1 demonstrates intracellular target-binding capability below 5 μM [1].
Chemical Properties
Molecular Weight436.244
FormulaC18H17IN2O3
Cas No.2361545-75-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

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