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PROTAC BET degrader-2

Name: PROTAC BET degrader-2
Brand: TargetMol
SKU: T12559
Rating: 4.5 (1 reviews)

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Catalog No. T12559Cas No. 2093388-33-9

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM.

PROTAC BET degrader-2

😃Good

Catalog No. T12559Cas No. 2093388-33-9

PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM.

Pack Size	Price	Availability
5 mg	$398	Backorder
10 mg	$631	Backorder
25 mg	$1,170	Backorder
50 mg	Inquiry	Backorder
100 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$637	Backorder

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Product Introduction

Bioactivity

Description	PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM.
Targets&IC50	BET (RS4;11 cells):9.6 nM
In vitro	PROTAC BET degrader-2 is a highly potent Bromodomain and Extra-Terminal (BET) proteins degrader (IC50 value of 9.6 nM in cell growth inhibition in the RS4);11 cells and capable of achieving tumor regression[1].

Chemical Properties

Molecular Weight	770.84
Formula	C₄₁H₄₂N₁₀O₆
Cas No.	2093388-33-9
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (64.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2973 mL	6.4864 mL	12.9729 mL	64.8643 mL
5 mM	0.2595 mL	1.2973 mL	2.5946 mL	12.9729 mL
10 mM	0.1297 mL	0.6486 mL	1.2973 mL	6.4864 mL
20 mM	0.0649 mL	0.3243 mL	0.6486 mL	3.2432 mL
50 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc