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ADU-S100 ammonium salt

Name: ADU-S100 ammonium salt
Brand: TargetMol
SKU: T10252L2
Rating: 4.5 (1 reviews)

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Catalog No. T10252L2Cas No. 1638750-96-5

Alias ML RR-S2 CDA ammonium salt, MIW815 ammonium salt

ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.

ADU-S100 ammonium salt

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Purity: 98%

Catalog No. T10252L2Alias ML RR-S2 CDA ammonium salt, MIW815 ammonium saltCas No. 1638750-96-5

ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$1,250	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.
In vitro	METHODS: BMDCs were treated with free ADU-S100 (0.5 μg/mL) or liposomal ADU-S100 (0.1 μg/mL) for 24 hours, and IFNβ (A) and TNFα (B) levels in the cell culture medium were measured using ELISA. RESULTS ADU-S100 enhanced the production of TNFα and IFNβ in BMDCs. [1] METHODS: Mouse cDC2 and human cDC2 were cultured in 12.5-200 μM ADU-S100 for 24 hours, and the effects of ADU-S100 on cDC2 were observed. RESULTS 25 μM ADU-S100 increased the expression of Tim-3 on DC, showing a significant upregulation of Tim-3. [3]
In vivo	METHODS: After a 50 μg bolus injection of ADU-S100 on day 14 after intracranial implantation of GL261 mice, brain infiltrating leukocytes (BILs) were analyzed in detail by flow cytometry using a panel of 13 immune markers. RESULTS Three days after treatment of ADU-S100, suppression of microglia, CD4+ and CD8+ T cell populations, and infiltration of NK and CD11b/Gr1 inflammatory immune cells were observed, and 7 days after treatment, the proportion of T cells recovered and increased compared to baseline levels. CD45-negative cells decreased shortly after treatment. [2] METHODS: B16F1-OVA cells/100 μL PBS were injected into the right groin of C57BL/6 mice, and tumor-bearing mice were treated intratumorally with saline and 50 μg ADU-S100 every 2 days during the first week. Then, the dose of S100 was reduced to 30 μg, while the frequency of administration remained unchanged. RESULTS Mice treated with ADU-S100 lost weight and had smaller tumors. [3]
Synonyms	ML RR-S2 CDA ammonium salt, MIW815 ammonium salt

Chemical Properties

Molecular Weight	724.6
Formula	C₂₀H₃₀N₁₂O₁₀P₂S₂
Cas No.	1638750-96-5
Smiles	NC1=C(C2=NC=N1)N=CN2[C@@H]3O[C@]([H])(CO4)[C@@]([H])(O[P@@](OC[C@@]5([C@]([H])([C@]([H])([C@@H](O5)N6C7=NC=NC(N)=C7N=C6)O[P@@]4(S)=O)O)[H])(S)=O)[C@H]3O.N.N
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 5 mg/mL (6.9 mM), Sonication is recommended.

DMSO: 12 mg/mL (16.56 mM), Sonication and heating are recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3801 mL	6.9004 mL	13.8007 mL	69.0036 mL
5 mM	0.2760 mL	1.3801 mL	2.7601 mL	13.8007 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1380 mL	0.6900 mL	1.3801 mL	6.9004 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc