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LTV-1

Name: LTV-1
Brand: TargetMol
SKU: T11889
Rating: 4.5 (1 reviews)

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Catalog No. T11889Cas No. 347379-29-7

LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM.

LTV-1

😃Good

Catalog No. T11889Cas No. 347379-29-7

LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM.

Pack Size	Price	Availability
25 mg	$688	6-8 weeks
50 mg	$913	6-8 weeks
100 mg	$1,390	6-8 weeks

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Product Introduction

Bioactivity

Description	LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM.
Targets&IC50	LYP (T cells):508 nM
In vitro	LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC)[1].even at the highest concentration tested (40 μM).

Chemical Properties

Molecular Weight	472.51
Formula	C₂₆H₂₀N₂O₅S
Cas No.	347379-29-7
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1164 mL	10.5818 mL	21.1636 mL	105.8179 mL
5 mM	0.4233 mL	2.1164 mL	4.2327 mL	21.1636 mL
10 mM	0.2116 mL	1.0582 mL	2.1164 mL	10.5818 mL
20 mM	0.1058 mL	0.5291 mL	1.0582 mL	5.2909 mL
50 mM	0.0423 mL	0.2116 mL	0.4233 mL	2.1164 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0582 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc