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Pumosetrag Hydrochloride

Name: Pumosetrag Hydrochloride
Brand: TargetMol
SKU: T16683
Rating: 4.5 (1 reviews)

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Catalog No. T16683Cas No. 194093-42-0

Alias MKC-733, DDP-733

Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

Pumosetrag Hydrochloride

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Catalog No. T16683Alias MKC-733, DDP-733Cas No. 194093-42-0

Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

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Product Introduction

Bioactivity

Description	Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
In vivo	Pumosetrag modulates gastrointestinal activity by delaying liquid gastric emptying through proximal stomach relaxation and enhancing fasting antroduodenal migrating motor complex activity, while also speeding up small intestinal transit. Its effectiveness varies across different sections of the mouse intestine, displaying minimal to no activity. This compound demonstrates regional and species-specific responses, with reduced efficacy compared to 5-HT in the rat's jejunum, ileum, and distal colon, yet showing comparable efficacy and potency in the rat's proximal colon. In contrast, Pumosetrag is more potent and effective than 5-HT across all regions of the guinea pig intestine. Its mechanism, mediated by 5-HT(3) receptors, is confirmed by the inhibitory effect of ondansetron on its actions in rat and guinea pig tissues.
Synonyms	MKC-733, DDP-733

Chemical Properties

Molecular Weight	339.84
Formula	C₁₅H₁₈ClN₃O₂S
Cas No.	194093-42-0
Smiles	Cl.O=C(N[C@H]1CN2CCC1CC2)c1c[nH]c2ccsc2c1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (88.28 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.5 mg/mL (4.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9426 mL	14.7128 mL	29.4256 mL	147.1281 mL
5 mM	0.5885 mL	2.9426 mL	5.8851 mL	29.4256 mL
10 mM	0.2943 mL	1.4713 mL	2.9426 mL	14.7128 mL
20 mM	0.1471 mL	0.7356 mL	1.4713 mL	7.3564 mL
50 mM	0.0589 mL	0.2943 mL	0.5885 mL	2.9426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc