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Malabaricone C

Name: Malabaricone C
Brand: TargetMol
SKU: TN6772
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6772Cas No. 63335-25-1

Malabaricone C is a bioactive chemical.

Malabaricone C

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Purity: 99.48%

Catalog No. TN6772Cas No. 63335-25-1

Malabaricone C is a bioactive chemical.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$256	In Stock	In Stock
25 mg	$432	In Stock	In Stock
50 mg	$622	-	In Stock
100 mg	$872	-	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Malabaricone C AI Summary

Malabaricone C exhibits a wide range of bioactivities indicating potential use in multiple therapeutic areas. It demonstrates significant antimicrobial activity against various strains of bacteria and fungi, with the highest efficacy observed against Bacillus subtilis and moderate activity against Candida albicans. Furthermore, it effectively cleaves Escherichia coli pBR322 DNA in the presence of copper and other agents, binds to calf thymus DNA, and induces reactive oxygen species (ROS) production in human MCF7 cells, with notable cytotoxic effects. Additionally, Malabaricone C reduces biofilm formation by Pseudomonas aeruginosa PAO1 and inhibits LPS-induced NO production in mouse RAW264.7 cells, suggesting anti-inflammatory properties. It also inhibits cholinesterases (both BChE and AChE), with pronounced inhibitory activity and a selectivity index favoring AChE. The compound inhibits sialidases from Streptococcus pneumoniae and has notable anti-diabetic effects by inhibiting digestive enzymes and enhancing glucose uptake in rat L6 cells. Moreover, Malabaricone C inhibits sphingomyelin synthases SMS1 and SMS2 in mouse ZS cells and shows anti-obesity effects in a high-fat diet-induced obesity mouse model. Collectively, these diverse bioactivities suggest that Malabaricone C may have multi-faceted therapeutic potential, spanning antimicrobial, anti-inflammatory, anti-diabetic, anti-obesity, and enzyme inhibition properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Malabaricone C is a bioactive chemical.

Chemical Properties

Molecular Weight	358.43
Formula	C₂₁H₂₆O₅
Cas No.	63335-25-1
Smiles	Oc1ccc(CCCCCCCCC(=O)c2c(O)cccc2O)cc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (418.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7899 mL	13.9497 mL	27.8995 mL	139.4973 mL
5 mM	0.5580 mL	2.7899 mL	5.5799 mL	27.8995 mL
10 mM	0.2790 mL	1.3950 mL	2.7899 mL	13.9497 mL
20 mM	0.1395 mL	0.6975 mL	1.3950 mL	6.9749 mL
50 mM	0.0558 mL	0.2790 mL	0.5580 mL	2.7899 mL
100 mM	0.0279 mL	0.1395 mL	0.2790 mL	1.3950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc