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Lidorestat

Name: Lidorestat
Brand: TargetMol
SKU: T15756
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15756Cas No. 245116-90-9

Alias IDD-676

Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.

Lidorestat

🥰Excellent

Purity: 99.98%

Catalog No. T15756Alias IDD-676Cas No. 245116-90-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$108	In Stock	In Stock
50 mg	$165	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.98%

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COA IC HNMR FNMR LCMS

Product Introduction

Bioactivity

Description	Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
Targets&IC50	Rldose reductase:5 nM
In vitro	Lidorestat's reported IC50 value for recombinant human aldose reductase (/h/-ALR2) in in vitro experiments is 5 μM. against recombinant human aldehyde reductase (/h/-ALR1), the selectivity ratio of /h/-ALR1 to /h/-ALR2 is 5400:1 [1,2].
In vivo	Lidorestat (25 mg/kg/day, oral administration, twice daily for 6 weeks) reduces fructose levels and lowers mortality rates in diabetic, hAR-expressing mice without affecting weight.[1]
Synonyms	IDD-676

Chemical Properties

Molecular Weight	376.35
Formula	C₁₈H₁₁F₃N₂O₂S
Cas No.	245116-90-9
Smiles	OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12
Relative Density.	1.55g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (132.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.66 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6571 mL	13.2855 mL	26.5710 mL	132.8551 mL
5 mM	0.5314 mL	2.6571 mL	5.3142 mL	26.5710 mL
10 mM	0.2657 mL	1.3286 mL	2.6571 mL	13.2855 mL
20 mM	0.1329 mL	0.6643 mL	1.3286 mL	6.6428 mL
50 mM	0.0531 mL	0.2657 mL	0.5314 mL	2.6571 mL
100 mM	0.0266 mL	0.1329 mL	0.2657 mL	1.3286 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc