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Lidorestat

🥰Excellent
Catalog No. T15756Cas No. 245116-90-9
Alias IDD-676

Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.

Lidorestat
Other Forms of Lidorestat:
Lidorestat monohydrateT68929653599-32-7
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Lidorestat

🥰Excellent
Purity: 99.98%
Catalog No. T15756Alias IDD-676Cas No. 245116-90-9
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$64In Stock
25 mg$108In Stock
50 mg$165In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.98%
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Product Introduction

Bioactivity
Description
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
Targets&IC50
Rldose reductase:5 nM
In vitro
Lidorestat's reported IC50 value for recombinant human aldose reductase (/h/-ALR2) in in vitro experiments is 5 μM. against recombinant human aldehyde reductase (/h/-ALR1), the selectivity ratio of /h/-ALR1 to /h/-ALR2 is 5400:1 [1,2].
In vivo
Lidorestat (25 mg/kg/day, oral administration, twice daily for 6 weeks) reduces fructose levels and lowers mortality rates in diabetic, hAR-expressing mice without affecting weight.[1]
SynonymsIDD-676
Chemical Properties
Molecular Weight376.35
FormulaC18H11F3N2O2S
Cas No.245116-90-9
SmilesOC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12
Relative Density.1.55g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (132.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6571 mL13.2855 mL26.5710 mL132.8551 mL
5 mM0.5314 mL2.6571 mL5.3142 mL26.5710 mL
10 mM0.2657 mL1.3286 mL2.6571 mL13.2855 mL
20 mM0.1329 mL0.6643 mL1.3286 mL6.6428 mL
50 mM0.0531 mL0.2657 mL0.5314 mL2.6571 mL
100 mM0.0266 mL0.1329 mL0.2657 mL1.3286 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Rldose reductaseLidorestatIDD676IDD 676Aldose reductase
Related Tags: buy Lidorestat | purchase Lidorestat | Lidorestat cost | order Lidorestat | Lidorestat chemical structure | Lidorestat in vivo | Lidorestat in vitro | Lidorestat formula | Lidorestat molecular weight
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