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Patritumab
(Synonyms: U3-1287, AMG-888) Copy Product Info
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Synonyms: U3-1287, AMG-888
Catalog No. T76796 Copy Product Info
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Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritumab promotes apoptosis and inhibits proliferation in non-small cell lung cancer.
Cas No. 1262787-83-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $297 | In Stock | In Stock | |
| 5 mg | $788 | In Stock | In Stock | |
| 10 mg | $1,230 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95.2% (SDS-PAGE); 98.2% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Patritumab (U3-1287) is an anti-HER3 monoclonal antibody with potential antitumor activity and inhibits phosphorylation of EGFR, HER2, HER3, ERK, and AKT.Patritumab promotes apoptosis and inhibits proliferation in non-small cell lung cancer. |
| In vitro | Patritumab targets the extracellular domain (ECD) of HER3 and induces apoptosis in DiFi-HRG4 cells (10 μg/mL; 5 days)[1]. Patritumab (10 μg/mL; 6 h) markedly inhibits the phosphorylation of HER3 and AKT in DiFi-HRG4 cells without affecting that of ERK[1]. Additionally, Patritumab (10 μg/mL; 48 h) induces the cleavage of PARP, accompanied by both up-regulation of BIM and down-regulation of survivin expression[1]. |
| In vivo | In a DiFi-HRG tumor xenografts model in mice, Patritumab (1 mg/mouse; intraperitoneal; twice a week for 4 weeks) combines with 1 mg Cetuximab and restores Cetuximab sensitivity[1]. Heregulin produced by colorectal cancer tumors harboring wild-type KRAS induces Cetuximab resistance, and combination therapy with cetuximab and patritumab overcomes such resistance in vivo[1]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | U3-1287, AMG-888 |
| Reactivity | Human |
| Verified Activity | Immobilized Human CD3e Protein (His) (TMPY-01191) at 1 μg/mL (100 μL/well) can bind Patritumab. The EC50 is 14.640 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ERBB3/HER3 |
| Molecular Weight | 146.97 kDa |
| Cas No. | 1262787-83-6 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Patritumab chemical structure | Patritumab in vivo | Patritumab in vitro | Patritumab molecular weight
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