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Anti-Cathepsin D Antibody (8K856)
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Catalog No. TMAY-02373
Alias HEL-S-130P, CPSD, CLN10, cathepsin D
Anti-Cathepsin D Antibody (8K856) is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Antibody (8K856) can be used in ELISA,ICC/IF.
Anti-Cathepsin D Antibody (8K856)
Anti-Cathepsin D Antibody (8K856)
😃Good
Catalog No. TMAY-02373Alias HEL-S-130P, CPSD, CLN10, cathepsin D
Anti-Cathepsin D Antibody (8K856) is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Antibody (8K856) can be used in ELISA,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Cathepsin D Antibody (8K856) is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Antibody (8K856) can be used in ELISA,ICC/IF. |
| Alias | HEL-S-130P, CPSD, CLN10, cathepsin D |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8K856 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of CTSD in A431 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human CTSD monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®594-conjugated Goat Anti-rabbit IgG secondary antibody (red) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm. |
| Application | ELISA,ICC/IF |
| Recommended Dose | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Cathepsin D / CTSD (rh Cathepsin D / CTSD; TMPY-02450; P07339; Met1-Leu412). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Cathepsin D / CTSD protein (TMPY-02450) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Sci Citations
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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