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ALK inhibitor 1

Name: ALK inhibitor 1
Brand: TargetMol
SKU: T10285
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10285Cas No. 761436-81-1

ALK inhibitor 1 is a selective ALK kinase inhibitor.

ALK inhibitor 1

🥰Excellent

Purity: 98.27%

Catalog No. T10285Cas No. 761436-81-1

ALK inhibitor 1 is a selective ALK kinase inhibitor.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$118	In Stock
10 mg	$178	In Stock
25 mg	$358	In Stock
50 mg	$497	In Stock
100 mg	$678	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock

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Batch Information

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Purity:98.27%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	ALK inhibitor 1 is a selective ALK kinase inhibitor.
Targets&IC50	IGF-1R: 90 nM
In vitro	ALK inhibitor 1 inhibits IGF-1R.

Chemical Properties

Molecular Weight	562.48
Formula	C₂₃H₂₈BrN₇O₃S
Cas No.	761436-81-1
Smiles	CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(C)CC2)ncc1Br
Relative Density.	1.472 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 0.1 mg/mL (insoluble)

DMSO: 90 mg/mL (160.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7778 mL	8.8892 mL	17.7784 mL	88.8920 mL
5 mM	0.3556 mL	1.7778 mL	3.5557 mL	17.7784 mL
10 mM	0.1778 mL	0.8889 mL	1.7778 mL	8.8892 mL
20 mM	0.0889 mL	0.4445 mL	0.8889 mL	4.4446 mL
50 mM	0.0356 mL	0.1778 mL	0.3556 mL	1.7778 mL
100 mM	0.0178 mL	0.0889 mL	0.1778 mL	0.8889 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc