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BIIL-260 hydrochloride

Name: BIIL-260 hydrochloride
Brand: TargetMol
SKU: T10543
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10543Cas No. 192581-24-1

Alias BIIL260 hydrochloride

BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils.

BIIL-260 hydrochloride

🥰Excellent

Purity: 98.89%

Catalog No. T10543Alias BIIL260 hydrochlorideCas No. 192581-24-1

Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$778	In Stock
50 mg	$1,190	In Stock
100 mg	$1,880	In Stock
200 mg	$2,530	In Stock
1 mL x 10 mM (in DMSO)	$273	In Stock

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Purity:98.89%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils.
Targets&IC50	LTB4-induced intracellular calcium release:0.82 nM, LTB4 receptor:1.7 nM (Ki)
In vitro	BIIL-260 hydrochloride binds to the LTB4 receptor in a reversible, competitive and saturable manner, exhibiting high affinity for the LTB4 receptor on isolated human neutrophil membranes, with a Ki value of 1.7 nM.In addition, BIIL-260 hydrochloride significantly inhibits LTB4-induced intracellular calcium release in human neutrophils, with an IC50 value of 0.82 nM. [1]
In vivo	In a monkey model, a single oral dose of 0.3 mg/kg of BIIL-260 hydrochloride completely inhibited LTB(4) receptor activity within 24 hours by detecting LTB(4)-induced neutropenia or Mac1 expression. [1]
Synonyms	BIIL260 hydrochloride

Chemical Properties

Molecular Weight	503.03
Formula	C₃₀H₃₁ClN₂O₃
Cas No.	192581-24-1
Smiles	Cl.N=C(N)C1=CC=C(OCC2=CC=CC(=C2)COC3=CC=C(C=C3)C(C4=CC=C(O)C=C4)(C)C)C=C1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (198.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9880 mL	9.9398 mL	19.8795 mL	99.3977 mL
5 mM	0.3976 mL	1.9880 mL	3.9759 mL	19.8795 mL
10 mM	0.1988 mL	0.9940 mL	1.9880 mL	9.9398 mL
20 mM	0.0994 mL	0.4970 mL	0.9940 mL	4.9699 mL
50 mM	0.0398 mL	0.1988 mL	0.3976 mL	1.9880 mL
100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.9940 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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