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BIIL-260 hydrochloride

Name: BIIL-260 hydrochloride
Brand: TargetMol
SKU: T10543
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10543Cas No. 192581-24-1

Alias BIIL260 hydrochloride

BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils.

BIIL-260 hydrochloride

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Purity: 98.89%

Catalog No. T10543Alias BIIL260 hydrochlorideCas No. 192581-24-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$396	In Stock	In Stock
25 mg	$778	In Stock	In Stock
50 mg	$1,190	In Stock	In Stock
100 mg	$1,880	-	In Stock
200 mg	$2,530	-	In Stock
1 mL x 10 mM (in DMSO)	$273	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BIIL-260 hydrochloride is an orally active and highly efficient leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, inhibiting LTB4-induced intracellular Ca2+ release in human neutrophils.
Targets&IC50	LTB4-induced intracellular calcium release:0.82 nM, LTB4 receptor:1.7 nM (Ki)
In vitro	BIIL-260 hydrochloride binds to the LTB4 receptor in a reversible, competitive and saturable manner, exhibiting high affinity for the LTB4 receptor on isolated human neutrophil membranes, with a Ki value of 1.7 nM.In addition, BIIL-260 hydrochloride significantly inhibits LTB4-induced intracellular calcium release in human neutrophils, with an IC50 value of 0.82 nM. [1]
In vivo	In a monkey model, a single oral dose of 0.3 mg/kg of BIIL-260 hydrochloride completely inhibited LTB(4) receptor activity within 24 hours by detecting LTB(4)-induced neutropenia or Mac1 expression. [1]
Synonyms	BIIL260 hydrochloride

Chemical Properties

Molecular Weight	503.03
Formula	C₃₀H₃₁ClN₂O₃
Cas No.	192581-24-1
Smiles	Cl.N=C(N)C1=CC=C(OCC2=CC=CC(=C2)COC3=CC=C(C=C3)C(C4=CC=C(O)C=C4)(C)C)C=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (198.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9880 mL	9.9398 mL	19.8795 mL	99.3977 mL
5 mM	0.3976 mL	1.9880 mL	3.9759 mL	19.8795 mL
10 mM	0.1988 mL	0.9940 mL	1.9880 mL	9.9398 mL
20 mM	0.0994 mL	0.4970 mL	0.9940 mL	4.9699 mL
50 mM	0.0398 mL	0.1988 mL	0.3976 mL	1.9880 mL
100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.9940 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc