Anti-ATG5 Polyclonal Antibody

Name: Anti-ATG5 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00163
Rating: 4.5 (1 reviews)

(Synonyms: Autophagy protein 5, ATG5, ASP, Apoptosis-specific protein, APG5-like, APG5L) Copy Product Info

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Synonyms: Autophagy protein 5, ATG5, ASP, Apoptosis-specific protein, APG5-like, APG5L

Catalog No. TMAB-00163 Copy Product Info

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Anti-ATG5 Polyclonal Antibody is a Rabbit antibody targeting ATG5. Anti-ATG5 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.

Anti-ATG5 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-ATG5 Polyclonal Antibody is a Rabbit antibody targeting ATG5. Anti-ATG5 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.
Synonyms	Autophagy protein 5, ATG5, ASP, Apoptosis-specific protein, APG5-like, APG5L
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm. Note=Colocalizes with nonmuscle actin.
Tissue Specificity	Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	In yeast, autophagy is an essential process for survival during nutrient starvation and cell differentiation. The process of autophagy is characterized as a non-selective degradation of cytoplasmic proteins into membrane stuctures called autophagosomes, and it is dependent on several proteins, including the autophagy proteins APG5 and APG7. Yeast Apg7 and the human homolog, APG7, share similarities with the ubiquitin-activating enzyme E1 in Saccharomyces cerevisiae and are likewise responsible for enzymatically activating the autophagy conjugation system. Apg5 and the human homolog, APG5 (also designated apoptosis-specific protein or APS), function as substrates for the autophagy protein Apg12. These proteins are covalently bonded together to form Apg12/APG5 conjugates, which are required for the progression of autophagy.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human APG5L
Antigen Species	Human
Gene Name	ATG5
Gene ID	9474
Protein Name	Autophagy protein 5
Uniprot ID	Q9H1Y0
Biology Area	Metabolism,Phagocytosis,APG gene products,Signal Transduction,Autophagy,APG gene products,Associated Proteins,Phagocytosis,Ub-like Proteins,Apoptosis,Autophagy and mitophagy,APG gene products
Function	Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.