Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Steroid sulfatase-IN-2 is an active inhibitor of steroid sulfatase (STS), demonstrating an IC50 value of 109.5 nM. Its potential application lies in hormone-dependent cancer research, specifically estrogen-dependent breast and endometrial cancer [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Steroid sulfatase-IN-2 is an active inhibitor of steroid sulfatase (STS), demonstrating an IC50 value of 109.5 nM. Its potential application lies in hormone-dependent cancer research, specifically estrogen-dependent breast and endometrial cancer [1]. |
In vitro | Steroid sulfatase-IN-2 (compound 1h), at concentrations ranging from 0.001-10 μM for 1 hour, effectively inhibits STS activity in JEG-3 cell lysates, demonstrating an IC50 of 109.5 nM. When applied at 1-10 μM for 20 hours in a whole-cell assay with JEG-3 cells, its inhibitory capability improves, showcasing an IC50 value of 13.6 nM. Additionally, over a 5-day exposure at 0.01-100 μM, Steroid sulfatase-IN-2 exhibits a dose-dependent antiproliferative effect on T-47D estrogen-dependent breast cancer cells, achieving an IC50 of 5.78 μM, as evidenced in a cell viability assay. |
Molecular Weight | 350.43 |
Formula | C17H22N2O4S |
CAS No. | 2413880-39-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Steroid sulfatase-IN-2 2413880-39-2 inhibitor inhibit