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ZINC194100678

Catalog No. T60269   CAS 1995025-05-2

ZINC194100678 is an effective PAK1 inhibitor with IC50 of 8.37μM. ZINC194100678 showed strong anti-proliferation activity, with IC50 value of 40.16μM against MDA-MB-231.

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ZINC194100678 Chemical Structure
ZINC194100678, CAS 1995025-05-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 195.00
5 mg In stock $ 448.00
10 mg In stock $ 658.00
25 mg In stock $ 987.00
50 mg In stock $ 1,380.00
100 mg In stock $ 1,890.00
500 mg In stock $ 3,780.00
1 mL * 10 mM (in DMSO) In stock $ 373.00
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Purity: 98.3%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ZINC194100678 is an effective PAK1 inhibitor with IC50 of 8.37μM. ZINC194100678 showed strong anti-proliferation activity, with IC50 value of 40.16μM against MDA-MB-231.
Targets&IC50 Antiproliferatory activity of cells:40.16 μM, PAK1:8.37 μM
In vitro ZINC194100678, at concentrations ranging from 0-50 μM over 48 hours, exhibits potent antiproliferative effects, as evidenced by an IC50 value of 40.16 μM, in the MDA-MB-231 cell line. This is demonstrated through a cell proliferation assay [1].
Molecular Weight 219.24
Formula C10H13N5O
CAS No. 1995025-05-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.19 mg/mL (10 mM)

TargetMolReferences and Literature

1. Zhang J, et al. Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells. Eur J Med Chem. 2020;194:112220.

Related compound libraries

This product is contained In the following compound libraries:
Cytoskeletal Signaling Pathway Compound Library Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library

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Keywords

ZINC194100678 1995025-05-2 Cytoskeletal Signaling PAK inhibitor inhibit

 

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