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HSV-gB2 (498-505)

Name: HSV-gB2 (498-505)
Brand: TargetMol
SKU: TP1534
Rating: 4.5 (1 reviews)

(Synonyms: HSV-gB2 498-505) Copy Product Info

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Synonyms: HSV-gB2 498-505

Catalog No. TP1534 Copy Product Info

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HSV-gB2 (498-505) is an immunodominant epitope derived from glycoprotein B of herpes simplex virus (HSV), corresponding to amino acid residues 498 to 505 of the protein. This epitope serves as a recognition target for cytotoxic T lymphocytes (CTLs) that are H-2Kb-restricted and cross-reactive against HSV-1 and HSV-2.

Cas No. 149997-91-1

Pack Size	Price	USA Stock	Global Stock	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	HSV-gB2 (498-505) is an immunodominant epitope derived from glycoprotein B of herpes simplex virus (HSV), corresponding to amino acid residues 498 to 505 of the protein. This epitope serves as a recognition target for cytotoxic T lymphocytes (CTLs) that are H-2Kb-restricted and cross-reactive against HSV-1 and HSV-2.
In vivo	Method: C57BL/6 mice were immunized once in the rear footpads with 200 μg of the gB498-505 synthetic peptide (emulsified in TiterMax adjuvant). Eight days later, popliteal lymph node cells were harvested and cultured in vitro for 3 days without antigenic stimulation. Cytolytic activity was assessed using a ⁵¹Cr release assay against B6/WT-3 target cells either infected with HSV-1 or pulsed with the gB498-505 peptide. The phenotype of the effector cells was identified by treatment with antibody and complement. Results: Lymph node cells from immunized mice acquired the ability to specifically lyse both HSV-1-infected and gB498-505-pulsed target cells in the absence of in vitro antigenic restimulation. This lytic activity was dependent on CD8⁺ T cells, whereas depletion of CD4⁺ T cells did not reduce the killing effect. These findings indicate that gB498-505 can induce the differentiation of CD8⁺ CTLs in vivo to an antigen-independent maturation stage [1].
Synonyms	HSV-gB2 498-505

Chemical Properties

Molecular Weight	922.04
Formula	C₄₁H₆₇N₁₁O₁₃
Cas No.	149997-91-1
Smiles	[C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CO)=O)[C@H](CC)C)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCCNC(=N)N)=O)C)=O
Relative Density.	1.41 g/cm3 (Predicted)
Sequence	Ser-Ser-Ile-Glu-Phe-Ala-Arg-Leu
Sequence Short	SSIEFARL

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble)

H2O: 4.7 mg/mL (5.1 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.0846 mL	5.4228 mL	10.8455 mL	54.2276 mL
5 mM	0.2169 mL	1.0846 mL	2.1691 mL	10.8455 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc