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Anti-CA9/Carbonic Anhydrase IX Antibody (7N753)
😃Good
Catalog No. TMAY-00268
Alias RCC, PMW1, P54/58N, MN, G250, EC 4.2.1.1, Carbonic Anhydrase IX, CA-IX, CAIX, CA9
Anti-CA9/Carbonic Anhydrase IX Antibody (7N753) is a Mouse antibody targeting CA9/Carbonic Anhydrase IX. Anti-CA9/Carbonic Anhydrase IX Antibody (7N753) can be used in IHC-P.
Anti-CA9/Carbonic Anhydrase IX Antibody (7N753)
Anti-CA9/Carbonic Anhydrase IX Antibody (7N753)
😃Good
Catalog No. TMAY-00268Alias RCC, PMW1, P54/58N, MN, G250, EC 4.2.1.1, Carbonic Anhydrase IX, CA-IX, CAIX, CA9
Anti-CA9/Carbonic Anhydrase IX Antibody (7N753) is a Mouse antibody targeting CA9/Carbonic Anhydrase IX. Anti-CA9/Carbonic Anhydrase IX Antibody (7N753) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | RCC, PMW1, P54/58N, MN, G250, EC 4.2.1.1, Carbonic Anhydrase IX, CA-IX, CAIX, CA9 |
| Ig Type | Mouse IgG1 |
| Clone | 7N753 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CAIX in human stomach with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human CAIX in human renal carcinoma with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Carbonic Anhydrase IX/CA9 (rh Carbonic Anhydrase IX/CA9; TMPY-00690; NP_001207.2; Met1-Asp414). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Carbonic Anhydrase IX/CA9 Protein (TMPY-00690) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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