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Anti-AKT1 Monoclonal Antibody (4C448)
(Synonyms: RAC-ALPHA, RAC, PRKBA, PKB-ALPHA, PKB, CWS6, AKT) Copy Product Info
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Synonyms: RAC-ALPHA, RAC, PRKBA, PKB-ALPHA, PKB, CWS6, AKT
Catalog No. TMAT-0049 Copy Product Info
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Anti-AKT1 Monoclonal Antibody (4C448) is a Mouse antibody targeting AKT1. Anti-AKT1 Monoclonal Antibody (4C448) can be used in WB,IHC,FCM.
Anti-AKT1 Monoclonal Antibody
(4C448)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-AKT1 Monoclonal Antibody (4C448) is a Mouse antibody targeting AKT1. Anti-AKT1 Monoclonal Antibody (4C448) can be used in WB,IHC,FCM. |
| Synonyms | RAC-ALPHA, RAC, PRKBA, PKB-ALPHA, PKB, CWS6, AKT |
| Ig Type | IgG1 |
| Clone | 4C448 |
| Reactivity | Human,Rat,Monkey |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human AKT1 (AA: 1-150) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | AKT1 |
| Gene ID | |
| Protein Name | RAC-alpha serine/threonine-protein kinase |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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