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Dendrophenol

Name: Dendrophenol
Brand: TargetMol
SKU: T3S1707
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S1707Cas No. 108853-14-1

Alias Moscatilin

Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.

Dendrophenol

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Purity: 99.36%

Catalog No. T3S1707Alias MoscatilinCas No. 108853-14-1

Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	In Stock	In Stock
2 mg	$148	In Stock	In Stock
5 mg	$239	In Stock	In Stock
10 mg	$355	In Stock	In Stock
25 mg	$588	In Stock	In Stock
50 mg	$838	In Stock	In Stock
100 mg	$1,130	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$259	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.36%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Dendrophenol AI Summary

Dendrophenol is a multifaceted bioactive molecule that exhibits significant activities across various biological domains. It demonstrates strong antioxidant activity, with a DPPH radical scavenging IC50 value of 14500.0 nM, and inhibits copper-induced lipid peroxidation in human LDL by 7.8%. The compound also displays potent anti-inflammatory activity, inhibiting LPS-induced NO production in mouse RAW 264.7 cells with an IC50 value of 27600.0 nM and additional spasmolytic properties in the guinea pig ileum, showcasing an IC50 value of 560.0 nM and an Emax of 73.63%, comparable to papaverine. Moreover, Dendrophenol exhibits notable antiproliferative and cytotoxic effects against various human cancer cell lines, including strong activity against MDA-MB-231 cells with an IC50 of 82.0 nM. It also inhibits cell growth in HepG2 and HCCLM3 cells with IC50 values of 3020.0 nM and 2092.0 nM, respectively. The compound further demonstrates anti-angiogenic activity in a zebrafish model, reducing inter-segmental blood vessels at a minimum effective dose of 2.5 μM. In addition, it has shown significant antiplatelet activity against washed rabbit platelets, inhibiting platelet aggregation induced by various stimuli. Dendrophenol also affects the cell cycle in OA-induced human SH-SY5Y cells, leading to cell cycle arrest at the sub-G1 phase at 0.1 μM concentration. These diverse biological activities indicate the compound's potential for further exploration in antioxidative, anti-inflammatory, anticancer, and angiogenesis-related research..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.
Synonyms	Moscatilin

Chemical Properties

Molecular Weight	304.34
Formula	C₁₇H₂₀O₅
Cas No.	108853-14-1
Smiles	COc1cc(CCc2cc(OC)c(O)c(OC)c2)ccc1O
Relative Density.	1.208g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (328.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2858 mL	16.4290 mL	32.8580 mL	164.2899 mL
5 mM	0.6572 mL	3.2858 mL	6.5716 mL	32.8580 mL
10 mM	0.3286 mL	1.6429 mL	3.2858 mL	16.4290 mL
20 mM	0.1643 mL	0.8214 mL	1.6429 mL	8.2145 mL
50 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2858 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6429 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc