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Pomalidomide-amido-C1-Br

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Catalog No. T18552Cas No. 2351106-38-0

Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].

Pomalidomide-amido-C1-Br

Pomalidomide-amido-C1-Br

😃Good
Catalog No. T18552Cas No. 2351106-38-0
Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].
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2 mg$1695 days5 days
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].
In vitro
Pomalidomide-amido-C1-Br (Compound 6) serves as a precursor for synthesizing PROTAC B-Raf degrader 1 (Compound 2), an effective anticancer agent that induces apoptosis in cancer cells by accelerating B-Raf degradation via the ubiquitin-proteasome system, affecting Mcl-1 expression, a downstream protein associated with B-Raf, highlighting its mechanism of action[1].
Chemical Properties
Molecular Weight394.18
FormulaC15H12BrN3O5
Cas No.2351106-38-0
Relative Density.1.808 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

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