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MEDI-570
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Catalog No. T9901A-1359 Copy Product Info
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MEDI-570 is a humanized IgG1 monoclonal antibody produced in CHO cells, targeting the inducible T-cell costimulator (ICOS/CD278). Functioning as a potent agonist, it binds with high affinity to the ICOS receptor, mimicking and amplifying the costimulatory signal of its natural ligand, ICOS-L. This agonistic activity promotes the activation, proliferation, survival, and cytokine production of T cells, including effector T cells and T follicular helper (Tfh) cells. It is developed as a cancer immunotherapeutic agent designed to combat tumors by enhancing T-cell function.
Cas No. 2179209-59-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $398 | Inquiry | Inquiry | |
| 5 mg | $1,190 | Inquiry | Inquiry | |
| 10 mg | $1,890 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Chemical Properties
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| Description | MEDI-570 is a humanized IgG1 monoclonal antibody produced in CHO cells, targeting the inducible T-cell costimulator (ICOS/CD278). Functioning as a potent agonist, it binds with high affinity to the ICOS receptor, mimicking and amplifying the costimulatory signal of its natural ligand, ICOS-L. This agonistic activity promotes the activation, proliferation, survival, and cytokine production of T cells, including effector T cells and T follicular helper (Tfh) cells. It is developed as a cancer immunotherapeutic agent designed to combat tumors by enhancing T-cell function. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | ICOS/CD278 |
| Cas No. | 2179209-59-5 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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