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Proteases/Proteasome Proteases/ProteasomeCarboxypeptidase
A carboxypeptidase is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to aminopeptidases, which cleave peptide bonds at the N-terminus of proteins. Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation.
2-PMPA
T3440173039-10-6
2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) (IC50=300 pM).
- $61
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QTY
2-MPPA
T22497254737-29-6
2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.
- $48
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CPA inhibitor
T10876223532-02-3In house
CPA inhibitor (Carboxypeptidase inhibitor) is a potent carboxypeptidase A (CPA) inhibitor with a Ki of 0.32 μM.
- $52
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BAY-299
T145022080306-23-4
BAY-299 is an effecitve inhibitor of the bromodomain and PHD finger family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L with IC50s of 67 nM, 8 nM, and 106 nM, respectively.
- $43
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GNE-375
T274231926989-06-1In house
GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.
- $119
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CeMMEC1
Cited
T4345440662-09-9In house
CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).
- $30
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CitedCarboxypeptidase G2 (CPG2) Inhibitor
T10678192203-60-4
Carboxypeptidase G2 (CPG2) Inhibitor (CPG2 Inhibitor) is a new CPG2 Inhibitor with antitumor activity.
- $30
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CeMMEC13
T68011790895-25-8
CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).
- $39
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2-Benzylsuccinic acid
T8093884-33-3
2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is a metabolite produced by bacteria as they process xenobiotic compounds.
- $40
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GCPII-IN-1 TFA
T624231269794-89-9
GCPII-IN-1 TFA is a scaffold inhibitor of glutamate carboxypeptidase II (GCPII; PSMA) with a Ki of 44.3 nM.
- $132
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Mergetpa
T7823977102-28-4
Mergetpa, a carboxypeptidase inhibitor, impedes the conversion of kinins and B2 receptor antagonists into metabolites devoid of the C-terminal arginine [1].
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Histargin
T2550493361-66-1
Histargin is an enzyme inhibitor separated from Streptomyces roseoviridis.
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PMPA sodium
T25968373645-42-2
PMPA sodium is a potent and selective glutamate carboxypeptidase 2 (GCP II N-acetylated a-linked dipeptidase NAALADase) inhibitor.
- $1,520
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Monosodium 2-sulfoterephthalate
T20421219089-60-2
Monosodium 2-sulfoterephthalate (8) is an inhibitor of glutamate carboxypeptidase II.
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GCPII-IN-1
T384201025796-32-0
GCPII-IN-1 is a potent inhibitor scaffold targeting glutamate carboxypeptidase II (GCPII), also known as prostate-specific membrane antigen (PSMA). It exhibits a high affinity for GCPII, with a binding affinity (K i ) of 44.3 nanomolar (nM).
- $970
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Carboxypeptidase C
T761689046-67-7
Carboxypeptidase C, often utilized in biochemical research, is an enzyme that excises COOH-terminal lysine, arginine, and proline, in addition to various neutral, aliphatic, aromatic, and acidic protein amino acids from peptide chains [1].
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