Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Parecoxib

🥰Excellent
Catalog No. T1780Cas No. 198470-84-7
Alias Vorth-P, Valus-P, SC 69124

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

Parecoxib
Other Forms of Parecoxib:
Parecoxib sodiumT1780L198470-85-8
Backorder
View details

Parecoxib

🥰Excellent
Purity: 99.78%
Catalog No. T1780Alias Vorth-P, Valus-P, SC 69124Cas No. 198470-84-7
Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$30In StockIn Stock
25 mg$48In StockIn Stock
50 mg$73In StockIn Stock
100 mg$123In StockIn Stock
200 mg$179In StockIn Stock
500 mg$297In StockIn Stock
1 mL x 10 mM (in DMSO)$53In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.78%
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.
In vivo
Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].
SynonymsVorth-P, Valus-P, SC 69124
Chemical Properties
Molecular Weight370.42
FormulaC19H18N2O4S
Cas No.198470-84-7
SmilesCC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(NC(CC)=O)(=O)=O)C=C3
Relative Density.1.264 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 2 mg/mL (5.4 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 50 mg/mL (134.98 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.4 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.6996 mL13.4982 mL26.9964 mL134.9819 mL
5 mM0.5399 mL2.6996 mL5.3993 mL26.9964 mL
DMSO
1mg5mg10mg50mg
10 mM0.2700 mL1.3498 mL2.6996 mL13.4982 mL
20 mM0.1350 mL0.6749 mL1.3498 mL6.7491 mL
50 mM0.0540 mL0.2700 mL0.5399 mL2.6996 mL
100 mM0.0270 mL0.1350 mL0.2700 mL1.3498 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SC-69124SC69124rheumatoid arthritispostoperativePOCDParecoxibpainosteoarthritisInhibitorinhibitCyclooxygenasecoxibsCOX-2COXcognitive dysfunctionchronic inflammatory conditionanalgesia
Related Tags: buy Parecoxib | purchase Parecoxib | Parecoxib cost | order Parecoxib | Parecoxib chemical structure | Parecoxib in vivo | Parecoxib formula | Parecoxib molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.