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Parecoxib

Name: Parecoxib
Brand: TargetMol
SKU: T1780
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1780Cas No. 198470-84-7

Alias Vorth-P, Valus-P, SC 69124

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

Parecoxib

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Purity: 99.78%

Catalog No. T1780Alias Vorth-P, Valus-P, SC 69124Cas No. 198470-84-7

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$73	In Stock	In Stock
100 mg	$123	In Stock	In Stock
200 mg	$179	In Stock	In Stock
500 mg	$297	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.78%

Color:White

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COA

Product Introduction

Bioactivity

Description	Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.
In vivo	Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].
Synonyms	Vorth-P, Valus-P, SC 69124

Chemical Properties

Molecular Weight	370.42
Formula	C₁₉H₁₈N₂O₄S
Cas No.	198470-84-7
Smiles	CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(NC(CC)=O)(=O)=O)C=C3
Relative Density.	1.264 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2 mg/mL (5.4 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (134.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6996 mL	13.4982 mL	26.9964 mL	134.9819 mL
5 mM	0.5399 mL	2.6996 mL	5.3993 mL	26.9964 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2700 mL	1.3498 mL	2.6996 mL	13.4982 mL
20 mM	0.1350 mL	0.6749 mL	1.3498 mL	6.7491 mL
50 mM	0.0540 mL	0.2700 mL	0.5399 mL	2.6996 mL
100 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc